Mouse models of rhinovirus-induced disease and exacerbation of allergic airway inflammation

被引：288

作者：

Bartlett, Nathan W. ^{[1
,2
]}

Walton, Ross P. ^{[1
,2
]}

Edwards, Michael R. ^{[1
,2
]}

Aniscenko, Juliya ^{[1
,2
]}

Caramori, Gaetano ^{[3
]}

Zhu, Jie

Glanville, Nicholas ^{[1
,2
]}

Choy, Katherine J. ^{[5
]}

Jourdan, Patrick ^{[1
,2
]}

Burnet, Jerome ^{[1
,2
]}

Tuthill, Tobias J. ^{[6
]}

Pedrick, Michael S. ^{[7
]}

Hurle, Michael J. ^{[7
]}

Plumpton, Chris ^{[7
]}

Sharp, Nigel A. ^{[7
]}

Bussell, James N. ^{[7
]}

Swallow, Dallas M. ^{[8
]}

Schwarze, Jurgen ^{[1
,2
]}

Guy, Bruno

WAlmond, Jeffrey ^{[9
]}

Jeffery, Peter K. ^{[4
]}

Lloyd, Clare M. ^{[5
]}

Papi, Alberto ^{[3
]}

Killington, Richard A. ^{[6
]}

Rowlands, David J. ^{[6
]}

Blair, Edward D. ^{[7
]}

Clarke, Neil J. ^{[7
]}

Johnston, Sebastian L. ^{[1
,2
]}

机构：

[1] Wright Fleming Inst Infect & Immun, UK Natl Heart & Lung Inst, Dept Resp Med, London W2 1PG, England

[2] Univ London Imperial Coll Sci Technol & Med, UK Ctr Allerg Mech Asthma, Med Res Council & Asthma, London W2 1PG, England

[3] Univ Ferrara, Res Ctr Asthma & Chron Obstruct Pulm Dis, I-44100 Ferrara, Italy

[4] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Dept Populat Genet & Gene Therapy, London SW3 6NP, England

[5] Univ London Imperial Coll Sci Technol & Med, Natl Heart & Lung Inst, Leukocyte Biol Sect, London SW7 2AZ, England

[6] Univ Leeds, Fac Biol Sci, Inst Mol & Cellular Biol, Leeds LS2 9JT, W Yorkshire, England

[7] Galxosmithkline Med Res Ctr, Stevenage SG1 2NY, Herts, England

[8] UCL, Dept Biol, Galton Lab, London WC1E 6BT, England

[9] Sanofi Pasteur, F-69007 Lyon, France

来源：

NATURE MEDICINE | 2008年 / 14卷 / 02期

基金：

英国惠康基金; 英国医学研究理事会;

关键词：

D O I：

10.1038/nm1713

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Rhinoviruses cause serious morbidity and mortality as the major etiological agents of asthma exacerbations and the common cold. A major obstacle to understanding disease pathogenesis and to the development of effective therapies has been the lack of a small-animal model for rhinovirus infection. Of the 100 known rhinovirus serotypes, 90% (the major group) use human intercellular adhesion molecule-1 (ICAM-1) as their cellular receptor and do not bind mouse ICAM-1; the remaining 10% (the minor group) use a member of the low-density lipoprotein receptor family and can bind the mouse counterpart. Here we describe three novel mouse models of rhinovirus infection: minor-group rhinovirus infection of BALB/c mice, major-group rhinovirus infection of transgenic BALB/c mice expressing a mouse-human ICAM-1 chimera and rhinovirus- induced exacerbation of allergic airway inflammation. These models have features similar to those observed in rhinovirus infection in humans, including augmentation of allergic airway inflammation, and will be useful in the development of future therapies for colds and asthma exacerbations.

引用

页码：199 / 204

页数：6

共 30 条

[1] Lambda interferon (IFN-λ), a type III IFN, is induced by viruses and IFNs and displays potent antiviral activity against select virus infections in vivo [J].