Molecular Mediators of RNA Loading into Extracellular Vesicles

被引：45

作者：

Corrado, Chiara ^{[1
]}

Barreca, Maria Magdalena ^{[1
,2
]}

Zichittella, Chiara ^{[1
]}

Alessandro, Riccardo ^{[1
,3
]}

Conigliaro, Alice ^{[1
]}

机构：

[1] Univ Palermo, Dept Biomed Neurosci & Adv Diagnost BiND, Sect Biol & Genet, I-90133 Palermo, Italy

[2] Univ Palermo, Dept Biol Chem & Pharmaceut Sci & Technol STEBICE, I-90128 Palermo, Italy

[3] Natl Res Council CNR, Inst Biomed Res & Innovat IRIB, I-90146 Palermo, Italy

来源：

CELLS | 2021年 / 10卷 / 12期

关键词：

exosomes; extracellular vesicles; non-coding RNA; miRNAs; lncRNAs; NEUTRAL SPHINGOMYELINASE; SIGNALING PATHWAY; EXOSOMAL MIRNAS; IN-VITRO; CELLS; ESCRT; ANGIOGENESIS; EXPRESSION; MICRORNAS; DELIVERY;

D O I：

10.3390/cells10123355

中图分类号：

Q2 [细胞生物学];

学科分类号：

071013 [干细胞生物学];

摘要：

In the last decade, an increasing number of studies have demonstrated that non-coding RNA (ncRNAs) cooperate in the gene regulatory networks with other biomolecules, including coding RNAs, DNAs and proteins. Among them, microRNAs (miRNAs), long non-coding RNAs (lncRNAs) and circular RNAs (circRNAs) are involved in transcriptional and translation regulation at different levels. Intriguingly, ncRNAs can be packed in vesicles, released in the extracellular space, and finally internalized by receiving cells, thus affecting gene expression also at distance. This review focuses on the mechanisms through which the ncRNAs can be selectively packaged into extracellular vesicles (EVs).

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页数：14

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