Clathrin uncoating: Auxilin comes to life

被引：71

作者：

Lemmon, SK ^{[1
]}

机构：

[1] Case Western Reserve Univ, Sch Med, Dept Mol Biol & Microbiol, Cleveland, OH 44106 USA

来源：

CURRENT BIOLOGY | 2001年 / 11卷 / 02期

关键词：

D O I：

10.1016/S0960-9822(01)00010-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The DnaJ protein auxilin has been extensively studied in vitro as a cofactor for uncoating clathrin-coated vesicles by the chaperone Hsc70. Recent studies provide the first evidence that auxilin plays this role in vivo, and work on a new mammalian auxilin suggests the protein may have more complex cellular functions.

引用

页码：R49 / R52

页数：4

共 26 条

[1]

Bensen ES, 2000, GENETICS, V154, P83

[2] Sequential steps in clathrin-mediated synaptic vesicle endocytosis [J].

Brodin, L ;

Löw, P ;

Shupliakov, O .

CURRENT OPINION IN NEUROBIOLOGY, 2000, 10 (03) :312-320

[3]

Chen CY, 1998, GENETICS, V150, P577

[4] Novel protein kinases Ark1p and Prk1p associate with and regulate the cortical actin cytoskeleton in budding yeast [J].

Cope, MJTV ;

Yang, S ;

Shang, C ;

Drubin, DG .

JOURNAL OF CELL BIOLOGY, 1999, 144 (06) :1203-1218

[5] Essential role of phosphoinositide metabolism in synaptic vesicle recycling [J].

Cremona, O ;

Di Paolo, G ;

Wenk, MR ;

Lüthi, A ;

Kim, WT ;

Takei, K ;

Daniell, L ;

Nemoto, Y ;

Shears, SB ;

Flavell, RA ;

McCormick, DA ;

De Camilli, P .

CELL, 1999, 99 (02) :179-188

[6] Fission and uncoating of synaptic clathrin-coated vesicles are perturbed by disruption of interactions with the SH3 domain of endophilin [J].

Gad, H ;

Ringstad, N ;

Löw, P ;

Kjaerulff, O ;

Gustafsson, J ;

Wenk, M ;

Di Paolo, G ;

Nemoto, Y ;

Crum, J ;

Ellisman, MH ;

De Camilli, P ;

Shupliakov, O ;

Brodin, L .

NEURON, 2000, 27 (02) :301-312

[7] The auxilin-like phosphoprotein Swa2p is required for clathrin function in yeast [J].

Gall, WE ;

Higginbotham, MA ;

Chen, CY ;

Ingram, MF ;

Cyr, DM ;

Graham, TR .

CURRENT BIOLOGY, 2000, 10 (21) :1349-1358

[8] Role of cyclin G-associated kinase in uncoating clathrin-coated vesicles from non-neuronal cells [J].

Greener, T ;

Zhao, XH ;

Nojima, H ;

Eisenberg, E ;

Greene, LE .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (02) :1365-1370

[9]

GREENER T, 2001, IN PRESS NAT CELL BI

[10] ATP- and cytosol-dependent release of adaptor proteins from clathrin-coated vesicles: A dual role for Hsc70 [J].

Hannan, LA ;

Newmyer, SL ;

Schmid, SL .

MOLECULAR BIOLOGY OF THE CELL, 1998, 9 (08) :2217-2229

← 1 2 3 →