Transcranial alternating current stimulation for treating depression: a randomized controlled trial

被引：106

作者：

Wang, Hongxing ^{[1
,2
]}

Wang, Kun ^{[1
,3
]}

Xue, Qing ^{[1
]}

Peng, Mao ^{[1
]}

Yin, Lu ^{[4
]}

Gu, Xuecun ^{[3
]}

Leng, Haixia ^{[1
]}

Lu, Juan ^{[3
]}

Liu, Hongzhi ^{[3
]}

Wang, Di ^{[3
]}

Xiao, Jin ^{[3
]}

Sun, Zhichao ^{[1
]}

Li, Ning ^{[1
]}

Dong, Kai ^{[1
]}

Zhang, Qian ^{[1
]}

Zhan, Shuqin ^{[1
]}

Fan, Chunqiu ^{[1
]}

Min, Baoquan ^{[1
]}

Zhou, Aihong ^{[1
]}

Xie, Yunyan ^{[1
]}

Song, Haiqing ^{[1
]}

Ye, Jing ^{[1
]}

Liu, Aihua ^{[1
]}

Gao, Ran ^{[1
]}

Huang, Liyuan ^{[1
]}

Jiao, Lidong ^{[1
]}

Song, Yang ^{[1
]}

Dong, Huiqing ^{[1
]}

Tian, Zichen ^{[5
]}

Si, Tianmei ^{[6
,7
]}

Zhang, Xiangyang ^{[8
]}

Li, Xinmin ^{[9
]}

Kamiya, Atsushi ^{[10
]}

Cosci, Fiammetta ^{[11
]}

Gao, Keming ^{[12
]}

Wang, Yuping ^{[1
]}

机构：

[1] Capital Med Univ, Xuanwu Hosp,Natl Clin Res Ctr Geriatr Dis, Beijing Psychosomat Dis Consultat Ctr,Dept Neurol, Natl Ctr Neurol Disorders,Div Neuropsychiat & Psy, 45 Changchun St, Beijing 100053, Peoples R China

[2] Capital Med Univ, Ctr Epilepsy, Inst Sleep & Consciousness Disorders, Beijing Inst Brain Disorders, Beijing 100053, Peoples R China

[3] Beijing Puren Hosp, Dept Neurol, Beijing 100062, Peoples R China

[4] Peking Union Med Coll & Chinese Acad Med Sci, Fuwai Hosp, Med Res & Biometr Ctr, Natl Ctr Cardiovasc Dis, Beijing, Peoples R China

[5] Carleton Coll, Dept Biol, Northfield, MN 55057 USA

[6] Peking Univ, Minist Hlth, Key Lab Mental Hlth, Natl Clin Res Ctr Mental Disorders,Peking Univ Si, Beijing 100191, Peoples R China

[7] Peking Univ, Inst Mental Hlth, Beijing 100191, Peoples R China

[8] Chinese Acad Sci, Inst Psychol, CAS Key Lab Mental Hlth, Beijing 100101, Peoples R China

[9] Univ Alberta, Fac Med & Dent, Dept Psychiat, Edmonton, AB T6G 2B7, Canada

[10] Johns Hopkins Univ, Dept Psychiat & Behav Sci, Sch Med, Baltimore, MD 21287 USA

[11] Univ Florence, Dept Hlth Sci, I-50135 Florence, Italy

[12] Case Western Reserve Univ, Sch Med, Dept Psychiat, Cleveland, OH 44106 USA

来源：

BRAIN | 2022年 / 145卷 / 01期

基金：

北京市自然科学基金; 中国国家自然科学基金; 国家重点研发计划;

关键词：

drug-naive; efficacy; first-episode; major depressive disorder; transcranial alternating current stimulation; CRANIAL ELECTROTHERAPY STIMULATION; ELECTRICAL-STIMULATION; MAJOR DEPRESSION; DOUBLE-BLIND; FOLLOW-UP; EFFICACY; SAFETY; PERCEPTION; DISORDER; INSOMNIA;

D O I：

10.1093/brain/awab252

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

100204 [神经病学];

摘要：

Treatment of depression with antidepressants is partly effective. Transcranial alternating current stimulation can provide a non-pharmacological alternative for adult patients with major depressive disorder. However, no study has used the stimulation to treat first-episode and drug-naive patients with major depressive disorder. We used a randomized, double-blind, sham-controlled design to examine the clinical efficacy and safety of the stimulation in treating first-episode drug-naive patients in a Chinese Han population. From 4 June 2018 to 30 December 2019, 100 patients were recruited and randomly assigned to receive 20 daily 40-min, 77.5 Hz, 15 mA, one forehead and two mastoid sessions of active or sham stimulation (n = 50 for each group) in four consecutive weeks (Week 4), and were followed for additional 4-week efficacy/safety assessment without stimulation (Week 8). The primary outcome was a remission rate defined as the 17-item Hamilton Depression Rating Scale (HDRS-17) score <= 7 at Week 8. Secondary analyses were response rates (defined as a reduction of >= 50% in the HDRS-17), changes in depressive symptoms and severity from baseline to Week 4 and Week 8, and rates of adverse events. Data were analysed in an intention-to-treat sample. Forty-nine in the active and 46 in the sham completed the study. Twenty-seven of 50 (54%) in the active treatment group and 9 of 50 (18%) in the sham group achieved remission at the end of Week 8. The remission rate was significantly higher in the active group compared to that in the sham group with a risk ratio of 1.78 (95% confidence interval, 1.29, 2.47). Compared with the sham, the active group had a significantly higher remission rate at Week 4, response rates at Weeks 4 and 8, and a larger reduction in depressive symptoms from baseline to Weeks 4 and 8. Adverse events were similar between the groups. In conclusion, the stimulation on the frontal cortex and two mastoids significantly improved symptoms in first-episode drug-naive patients with major depressive disorder and may be considered as a non-pharmacological intervention for them in an outpatient setting. In a randomized double-blind controlled trial, Wang et al. show that 4 weeks of treatment with transcranial alternating current stimulation (tACS) reduces symptoms to a greater degree than sham stimulation in first-episode drug-naive patients with major depressive disorder.

引用

页码：83 / 91

页数：9

共 44 条

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Double-blind, randomized pilot clinical trial targeting alpha oscillations with transcranial alternating current stimulation (tACS) for the treatment of major depressive disorder (MDD) [J].