Duplicated members of the Groucho/Tle gene family in fish

被引:19
作者
Aghaallaei, N
Bajoghli, B
Walter, I
Czerny, T
机构
[1] Univ Vet Med, Inst Anim Breeding & Genet, A-1210 Vienna, Austria
[2] Univ Vet Med, Inst Hist & Embryol, Vienna, Austria
关键词
medaka; Groucho; Tle; expression pattern; otic development; gene duplication; Fugu; Tetraodon; zebrafish;
D O I
10.1002/dvdy.20510
中图分类号
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号
100101 ;
摘要
The highly conserved Groucho/Tle gene family has widespread functions during embryonic development and in adults. For mammalians, four full-length Tle paralogues are known, whereas the whole spectrum of this gene family in fish species has not been analysed yet. Most detailed data exist for medaka, where 3 Tle genes have been described, Tle1, Tle3, and Tle4. We now isolated 3 additional Tle genes from the medaka genome. Sequence analysis identifies these genes as Tle2a, Tle2b, and Tle3b. Database searches of genomic sequences revealed an identical set of Tle paralogues being present in distantly related fish species, indicating duplicated Tle2 and Tle3 genes for the complete teleost lineage. Like the previously analysed medaka Tle genes, the three new genes show a broad expression pattern during embryogenesis. Nevertheless, a detailed comparison of all six Tle genes reveals critical differences in certain aspects of their expression pattern. In particular, we concentrated on the activity of Tle genes during ear development and found Tle2a and Tle2b expressed in this sensory organ. (c) 2005 Wiley-Liss, Inc.
引用
收藏
页码:143 / 150
页数:8
相关论文
共 39 条
  • [1] Zebrafish hox clusters and vertebrate genome evolution
    Amores, A
    Force, A
    Yan, YL
    Joly, L
    Amemiya, C
    Fritz, A
    Ho, RK
    Langeland, J
    Prince, V
    Wang, YL
    Westerfield, M
    Ekker, M
    Postlethwait, JH
    [J]. SCIENCE, 1998, 282 (5394) : 1711 - 1714
  • [2] Vertebrate evolution - recent perspectives from fish
    Aparicio, S
    [J]. TRENDS IN GENETICS, 2000, 16 (02) : 54 - 56
  • [3] Groucho corepressor proteins regulate otic vesicle outgrowth
    Bajoghli, B
    Aghaallaei, N
    Czerny, T
    [J]. DEVELOPMENTAL DYNAMICS, 2005, 233 (03) : 760 - 771
  • [4] GeneWise and genomewise
    Birney, E
    Clamp, M
    Durbin, R
    [J]. GENOME RESEARCH, 2004, 14 (05) : 988 - 995
  • [5] All Tcf HMG box transcription factors interact with Groucho-related co-repressors
    Brantjes, H
    Roose, J
    van de Wetering, M
    Clevers, H
    [J]. NUCLEIC ACIDS RESEARCH, 2001, 29 (07) : 1410 - 1419
  • [6] Groucho suppresses Pax2 transactivation by inhibition of JNK-mediated phosphorylation
    Cai, Y
    Brophy, PD
    Levitan, I
    Stifani, S
    Dressler, GR
    [J]. EMBO JOURNAL, 2003, 22 (20) : 5522 - 5529
  • [7] Drosophila Tcf and Groucho interact to repress Wingless signalling activity
    Cavallo, RA
    Cox, RT
    Moline, MM
    Roose, J
    Polevoy, GA
    Clevers, H
    Peifer, M
    Bejsovec, A
    [J]. NATURE, 1998, 395 (6702) : 604 - 608
  • [8] Groucho/TLE family proteins and transcriptional repression
    Chen, GQ
    Courey, AJ
    [J]. GENE, 2000, 249 (1-2) : 1 - 16
  • [9] Cloning and developmental expression of Xenopus cDNAs encoding the Enhancer of split groucho and related proteins
    Choudhury, BK
    Kim, J
    Kung, HF
    Li, SSL
    [J]. GENE, 1997, 195 (01) : 41 - 48
  • [10] TLE EXPRESSION CORRELATES WITH MOUSE EMBRYONIC SEGMENTATION, NEUROGENESIS, AND EPITHELIAL DETERMINATION
    DEHNI, G
    LIU, YL
    HUSAIN, J
    STIFANI, S
    [J]. MECHANISMS OF DEVELOPMENT, 1995, 53 (03) : 369 - 381