Antimicrobial and cytotoxicity evaluation of Buchholzia coriacea stem bark

被引：32

作者：

Ajaiveoba, EO ^{[1
]}

Onocha, PA

Nwozo, SO

Sama, W

机构：

[1] Univ Ibadan, Dept Pharmacognosy, Ibadan, Nigeria

[2] Univ Ibadan, Dept Chem, Ibadan, Nigeria

[3] Univ Ibadan, Dept Biochem, Ibadan, Nigeria

来源：

FITOTERAPIA | 2003年 / 74卷 / 7-8期

关键词：

Buchholzia coriacea; antibacterial; antifungal; cytotoxicity; triterpenoids;

D O I：

10.1016/S0367-326X(03)00142-4

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Fractions prepared from the methanol extract of Buchholzia coriacea stem bark exhibited a high concentration-dependent antibacterial and antifungal activity compared to the standard antibiotics, ampicillin and tioconazole. In the brine shrimp lethality (BSL) assay, the methanol extract was found to be non-toxic with an LC50 of 1031 mug/ml. The two main compounds present in the most active fraction were isolated and identified as lupeol and P-sitosterol. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：706 / 709

页数：4