Regulation of neuronal nitric oxide synthase mRNA in lordosis-relevant neurons of the ventromedial hypothalamus following short-term estrogen treatment

被引：33

作者：

Rachman, IM

Unnerstall, JR

Pfaff, DW

Cohen, RS

机构：

[1] Univ Illinois, Dept Anat & Cell Biol MC 512, Chicago, IL 60612 USA

[2] Rockefeller Univ, Dept Neurobiol & Behav, New York, NY 10021 USA

来源：

MOLECULAR BRAIN RESEARCH | 1998年 / 59卷 / 01期

关键词：

estrogen; neuronal nitric oxide synthase; mRNA; ventromedial hypothalamus; in situ hybridization;

D O I：

10.1016/S0169-328X(98)00131-4

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Short-term estrogenic regulation of neuronal nitric oxide synthase (nNOS) mRNA in the ventrolateral subdivision of the ventromedial nucleus (VLVMN), an area central to lordosis, was demonstrated using in situ hybridization. Estrogen-treated animals showed a significantly greater signal in the VLVMN, but not the arcuate or supraoptic nuclei, compared to ovariectomized controls. Neuronal NOS may be involved in early actions of estrogen in the VLVMN. (C) 1998 Elsevier Science B.V. All rights reserved.

引用

页码：105 / 108

页数：4

共 23 条

[1] Evidence that brain nitric oxide synthase is the major nitric oxide synthase isoform in the hypothalamus of the adult female rat and that nitric oxide potently regulates hypothalamic cGMP levels [J].