KATP channel pharmacogenomics:: From bench to bedside

被引：34

作者：

Sattiraju, S. ^{[1
,2
]}

Reyes, S. ^{[1
,2
]}

Kane, G. C. ^{[1
,2
]}

Terzic, A. ^{[1
,1
,2
]}

机构：

[1] Mayo Clin, Dept Med Genet, Rochester, MN USA

[2] Mayo Clin, Dept Mol Pharmacol & Expt Therapeut, Rochester, MN USA

来源：

CLINICAL PHARMACOLOGY & THERAPEUTICS | 2008年 / 83卷 / 02期

关键词：

D O I：

10.1038/sj.clpt.6100378

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Inheritance plays a significant role in defining drug response and toxicity. Advances in molecular pharmacology and modern genomics emphasize genetic variation in dictating inter-individual pharmacokinetics and pharmacodynamics. A case in point is the homeostatic ATP-sensitive potassium (K-ATP) channel, an established drug target that adjusts membrane excitability to match cellular energetic demand. There is an increased recognition that genetic variability of the K-ATP channel impacts therapeutic decisionmaking in human disease.

引用

页码：354 / 357

页数：4

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