O-arylmandelic acids as highly selective human PPAR α/γ agonists

被引：26

作者：

Adams, AD

Hu, Z

von Langen, D

Dadiz, A

Elbrecht, A

MacNaul, KL

Berger, JP

Zhou, GC

Doebber, TW

Meurer, R

Forrest, MJ

Moller, DE

Jones, AB

机构：

[1] Merck & Co Inc, Merck Res Labs, Dept Med Chem, Rahway, NJ 07065 USA

[2] Merck & Co Inc, Merck Res Labs, Dept Mol Endocrinol, Rahway, NJ 07065 USA

[3] Merck & Co Inc, Merck Res Labs, Dept Anim Pharmacol, Rahway, NJ 07065 USA

[4] Merck Sharp & Dohme Ltd, Neurosci Res Ctr, Harlow CM20 2QR, Essex, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2003年 / 13卷 / 19期

关键词：

D O I：

10.1016/S0960-894X(03)00702-9

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A new class of O-arylmandelic acid PPAR agonists show excellent anti-hyperglycemic efficacy in a db/db mouse model of DM2. These PPARalpha-weighted agonists do not show the typical PPARgamma associated side effects of BAT proliferation and cardiac hypertrophy in a rat tolerability assay. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：3185 / 3190

页数：6

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