Deuterium exchange mediated by an iridium-phosphine complex formed in situ

被引：44

作者：

Ellames, GJ

Gibson, JS

Herbert, JM

Kerr, WJ

McNeill, AH

机构：

[1] Sanofi Synthelabo, Isotope Chem & Metabolite Synth Dept, Alnwick NE66 2JH, Northd, England

[2] Univ Strathclyde, Dept Pure & Appl Chem, Glasgow G1 1XL, Lanark, Scotland

来源：

TETRAHEDRON LETTERS | 2001年 / 42卷 / 36期

关键词：

iridium complexes; deuterium exchange; isotope exchange;

D O I：

10.1016/S0040-4039(01)01266-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Bis(triorganophosphine)(cyclooctadiene)iridium(I) tetrafluoroborates, 2, are readily generated in situ and utilised for the exchange of deuterium into a variety of aromatic substrates. The efficiencies of deuterium exchange using 2 formed in this way are comparable to those observed in exchange processes where the isolated pre-catalysts were used. (C) 2001 Elsevier Science Ltd. All rights reserved.

引用

页码：6413 / 6416

页数：4

共 11 条

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Chen W, 1997, J LABELLED COMPD RAD, V39, P291, DOI 10.1002/(SICI)1099-1344(199704)39:4<291::AID-JLCR973>3.0.CO

[2]

2-K

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