Major groove binding and 'DNA-induced' fit in the intercalation of a derivative of the mixed topoisomerase I/II poison N-(2-(dimethylamino)ethyl)acridine-4-carboxamide (DACA) into DNA:: X-ray structure complexed to d(CG(5-BrU)ACG)2 at 1.3-Å resolution

被引：99

作者：

Todd, AK

Adams, A

Thorpe, JH

Denny, WA

Wakelin, LPG

Cardin, CJ ^{[1
]}

机构：

[1] Univ Reading, Dept Chem, Reading RG6 2AD, Berks, England

[2] Univ Reading, Dept Chem, Reading RG6 6AD, Berks, England

[3] Univ Dublin Trinity Coll, Dept Biochem, Dublin 2, Ireland

[4] Univ Auckland, Fac Med & Hlth Sci, Canc Soc Res Ctr, Auckland 1, New Zealand

[5] Univ Coll Dublin, Dept Chem, Dublin 2, Ireland

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 1999年 / 42卷 / 04期

关键词：

D O I：

10.1021/jm980479u

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

引用

页码：536 / 540

页数：5

共 27 条

[1] POTENTIAL ANTITUMOR AGENTS .50. INVIVO SOLID-TUMOR ACTIVITY OF DERIVATIVES OF N-[2-(DIMETHYLAMINO)ETHYL]ACRIDINE-4-CARBOXAMIDE [J].

ATWELL, GJ ;

REWCASTLE, GW ;

BAGULEY, BC ;

DENNY, WA .

JOURNAL OF MEDICINAL CHEMISTRY, 1987, 30 (04) :664-669

[2] DIVERGENT ACTIVITY OF DERIVATIVES OF AMSACRINE (M-AMSA) TOWARDS LEWIS LUNG-CARCINOMA AND P388 LEUKEMIA IN MICE [J].

BAGULEY, BC ;

KERNOHAN, AR ;

WILSON, WR .

EUROPEAN JOURNAL OF CANCER & CLINICAL ONCOLOGY, 1983, 19 (11) :1607-1613

[3]

BAGULEY BC, 1995, CANCER CHEMOTH PHARM, V36, P244, DOI 10.1007/BF00685854

[4] Structure and mechanism of DNA topoisomerase II [J].

Berger, JM ;

Gamblin, SJ ;

Harrison, SC ;

Wang, JC .

NATURE, 1996, 379 (6562) :225-232

[5] Structure-based design fill of a new bisintercalating anthracycline antibiotic [J].

Chaires, JB ;

Leng, FF ;

Przewloka, T ;

Fokt, I ;

Ling, YH ;

PerezSoler, R ;

Priebe, W .

JOURNAL OF MEDICINAL CHEMISTRY, 1997, 40 (03) :261-266

[6] GROOVE SELECTIVITY IN THE INTERACTION OF 9-AMINOACRIDINE-4-CARBOXAMIDE ANTITUMOR AGENTS WITH DNA [J].

CHEN, KX ;

GRESH, N ;

PULLMAN, B .

FEBS LETTERS, 1987, 224 (02) :361-364

[7]

Denny W A, 1997, Expert Opin Investig Drugs, V6, P1845, DOI 10.1517/13543784.6.12.1845

[8] From amsacrine to DACA (N-[2-(dimethylamino)ethyl]acridine-4-carboxamide): Selectivity for topoisomerases I and II among acridine derivatives [J].

Finlay, GJ ;

Riou, JF ;

Baguley, BC .

EUROPEAN JOURNAL OF CANCER, 1996, 32A (04) :708-714

[9] CRYSTALLOGRAPHIC AND MOLECULAR MECHANICS CALCULATIONS ON THE ANTITUMOR DRUGS N-[(2-DIMETHYLAMINO)ETHYL]-AND N-[(2-DIMETHYL-AMINO)BUTYL]-9-AMINOACRIDINE-4-CARBOXAMIDES AND THEIR DICATIONS - IMPLICATIONS FOR MODELS OF DNA-BINDING [J].

HUDSON, BD ;

KURODA, R ;

DENNY, WA ;

NEIDLE, S .

JOURNAL OF BIOMOLECULAR STRUCTURE & DYNAMICS, 1987, 5 (01) :145-158

[10] DNA topoisomerase targeting drugs: mechanisms of action and perspectives [J].

Malonne, H ;

Atassi, G .

ANTI-CANCER DRUGS, 1997, 8 (09) :811-822

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