Effect of Vitamins C and E on cognitive function in mouse

被引：28

作者：

Arzi, A ^{[1
]}

Hemmati, AA ^{[1
]}

Razian, A ^{[1
]}

机构：

[1] Ahwaz Univ Med Sci, Sch Pharm, Dept Pharmacol & Toxicol, Ahvaz, Iran

来源：

PHARMACOLOGICAL RESEARCH | 2004年 / 49卷 / 03期

关键词：

cognition; Vitamin E; Vitamin C; step-down latency; mouse;

D O I：

10.1016/j.phrs.2003.10.004

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The aim of this study was to verify the role of Vitamins C and E on the cognitive function of young and aged mice. First and second groups of young animals (aged 3 months) received either Vitamin E (250 mg/kg per day) or Vitamin C (300 mg/kg per day) for 60 days. Third group was treated with the combination of Vitamin E (250 mg/kg per day) and Vitamin C (300 mg/kg per day) for 60 days. The control group received only vehicle. The aged animal group (aged 15 months) were treated as the young group. Passive avoidance method was used for the assessment of cognitive function in both young and aged animals. The results indicated a significant improvement in the cognitive function of aged mice while there were no significant changes in young animals. (C) 2003 Elsevier Ltd. All rights reserved.

引用

页码：249 / 252

页数：4

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