Epitope spreading within lupus-associated ribonucleoprotein antigens

被引：48

作者：

Deshmukh, US

Bagavant, H

Lewis, J

Gaskin, F

Fu, SM

机构：

[1] Univ Virginia, Specialised Ctr Res Systemat Lupus Erytjematosus, Div Rheumatol & Immunol, Charlottesville, VA 22908 USA

[2] Univ Virginia, Dept Psychiat Med, Charlottesville, VA 22908 USA

来源：

CLINICAL IMMUNOLOGY | 2005年 / 117卷 / 02期

关键词：

autoantibodies; autoimmunity; cross-reactivity; epitope spreading; intermolecular; intramolecular; ribonucleoproteins; Ro60; snRNP; systemic lupus erythematosus;

D O I：

10.1016/j.clim.2005.07.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Autoantibodies reactive with several cellular antigens are present in the sera of patients with systemic lupus erythematosus. Polypeptides within the Ro-RNP complex and the snRNP complex are often targeted by these autoantibodies. One of the mechanisms responsible for their evolution is that of epitope spreading. Experimental animal model systems provide evidence for this. This review discusses the animal model systems of epitope spreading within these ribonucleoprotein antigens, the mechanisms of epitope spreading, and its relevance for disease pathogenesis. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：112 / 120

页数：9

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