ATP synthase - A marvellous rotary engine of the cell

被引:727
作者
Yoshida, M [1 ]
Muneyuki, E [1 ]
Hisabori, T [1 ]
机构
[1] Tokyo Inst Technol, Chem Resources Lab, Yokohama, Kanagawa 2268503, Japan
关键词
D O I
10.1038/35089509
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
ATP synthase can be thought of as a complex of two motors - the ATP-driven Ft motor and the proton-driven F-o motor - that rotate in opposite directions. The mechanisms by which rotation and catalysis are coupled in the working enzyme are now being unravelled on a molecular scale.
引用
收藏
页码:669 / 677
页数:9
相关论文
共 77 条
[1]   STRUCTURE AT 2.8-ANGSTROM RESOLUTION OF F1-ATPASE FROM BOVINE HEART-MITOCHONDRIA [J].
ABRAHAMS, JP ;
LESLIE, AGW ;
LUTTER, R ;
WALKER, JE .
NATURE, 1994, 370 (6491) :621-628
[2]   Stepping rotation of F1-ATPase visualized through angle-resolved single-fluorophore imaging [J].
Adachi, K ;
Yasuda, R ;
Noji, H ;
Itoh, H ;
Harada, Y ;
Yoshida, M ;
Kinosita, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (13) :7243-7247
[3]   Identification of subunits a, b, and c1 from Acetobacterium woodii Na+-F1F0-ATPase -: Subunits c1, c2, and c3 constitute a mixed c-oligomer [J].
Aufurth, S ;
Schägger, H ;
Müller, V .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (43) :33297-33301
[4]  
BAID D, 2000, J BIOL CHEM, V275, P12757
[5]   ATP synthesis by F0F1-ATP synthase independent of noncatalytic nucleotide binding sites and insensitive to azide inhibition [J].
Bald, D ;
Amano, T ;
Muneyuki, E ;
Pitard, B ;
Rigaud, JL ;
Kruip, J ;
Hisabori, T ;
Yoshida, M ;
Shibata, M .
JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (02) :865-870
[6]   The ATP synthase - A splendid molecular machine [J].
Boyer, PD .
ANNUAL REVIEW OF BIOCHEMISTRY, 1997, 66 :717-749
[7]  
Boyer PD, 1998, ANGEW CHEM INT EDIT, V37, P2297, DOI 10.1002/(SICI)1521-3773(19980918)37:17<2296::AID-ANIE2296>3.0.CO
[8]  
2-W
[9]   Dimerization of bovine F1-ATPase by binding the inhibitor protein, IF1 [J].
Cabezón, E ;
Arechaga, I ;
Butler, PJG ;
Walker, JE .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (37) :28353-28355
[10]   Modulation of the oligomerization state of the bovine F1-ATPase inhibitor protein, IF1, by pH [J].
Cabezon, E ;
Butler, PJG ;
Runswick, MJ ;
Walker, JE .
JOURNAL OF BIOLOGICAL CHEMISTRY, 2000, 275 (33) :25460-25464