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FlyBase: introduction of the Drosophila melanogaster Release 6 reference genome assembly and large-scale migration of genome annotations

被引：293
作者：
dos Santos, Gilberto [1 ]
Schroeder, Andrew J. [1 ]
Goodman, Joshua L. [2 ]
Strelets, Victor B. [2 ]
Crosby, Madeline A. [1 ]
Thurmond, Jim [2 ]
Emmert, David B. [1 ]
Gelbart, William M. [1 ]
机构：
[1] Harvard Univ, Biol Labs, Cambridge, MA 02138 USA
[2] Indiana Univ, Dept Biol, Bloomington, IN 47405 USA
来源：
NUCLEIC ACIDS RESEARCH | 2015年 / 43卷 / D1期
基金：
美国国家卫生研究院; 英国医学研究理事会;
关键词：
SEQUENCE; GENERATION; BROWSER;
D O I：
10.1093/nar/gku1099
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Release 6, the latest reference genome assembly of the fruit fly Drosophila melanogaster, was released by the Berkeley Drosophila Genome Project in 2014; it replaces their previous Release 5 genome assembly, which had been the reference genome assembly for over 7 years. With the enormous amount of information now attached to the D. melanogaster genome in public repositories and individual laboratories, the replacement of the previous assembly by the new one is a major event requiring careful migration of annotations and genome-anchored data to the new, improved assembly. In this report, we describe the attributes of the new Release 6 reference genome assembly, the migration of FlyBase genome annotations to this new assembly, how genome features on this new assembly can be viewed in FlyBase (http://flybase.org) and how users can convert coordinates for their own data to the corresponding Release 6 coordinates.
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收藏
页码：D690 / D697
页数：8
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