Sorl1 as an Alzheimer's disease predisposition gene?

被引：61

作者：

Webster, Jennifer A. ^{[1
]}

Myers, AmandaJ. ^{[2
]}

Pearson, John V. ^{[1
]}

Craig, David W. ^{[1
]}

Diane, Hu-Lincea ^{[1
]}

Coon, Keith D. ^{[1
]}

Zismann, Victoria L. ^{[1
]}

Beach, Thomas ^{[3
,4
]}

Leunge, Doris ^{[5
]}

Bryden, Leslie ^{[5
]}

Halperin, Rebecca F. ^{[1
]}

Marlowe, Lauren ^{[5
]}

Kaleem, Mona ^{[5
]}

Huentelman, Matthew J. ^{[1
]}

Joshipura, Keta ^{[1
]}

Walker, Douglas ^{[3
,4
]}

Heward, Christopher B. ^{[6
]}

Ravidi, Rivka ^{[9
]}

Rogers, Joseph ^{[3
,4
]}

Papassotiropoulos, Andreas ^{[1
,10
]}

Hardy, John ^{[2
]}

Reiman, Eric M. ^{[1
,4
,7
,8
]}

Stephan, Dietrich A. ^{[1
,4
]}

机构：

[1] Translat Genom Res Inst, Neurogenom Div, Phoenix, AZ 85004 USA

[2] Univ Maine, Miller Sch Med, Dept Psychiat & Behav Sci, Miami, FL USA

[3] Sun Hlth Res Inst, Sun City, AZ USA

[4] Arizona Alzheimers Consortium, Phoenix, AZ USA

[5] NIA, Neurogenet Lab, NIH, Bethesda, MD USA

[6] Kronos Sci Labs, Phoenix, AZ USA

[7] Banner Alzheimers Inst, Phoenix, AZ USA

[8] Univ Arizona, Dept Psychiat, Tucson, AZ USA

[9] Royal Dutch Acad Sci, Amsterdam, Netherlands

[10] Univ Zurich, Dept Psychiat Res, Zurich, Switzerland

来源：

NEURODEGENERATIVE DISEASES | 2008年 / 5卷 / 02期

基金：

英国医学研究理事会;

关键词：

Sorl1; Alzheimer's disease; predisposition gene; APOE gene; sortilin-related receptor;

D O I：

10.1159/000110789

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressively disabling impairments in memory, cognition, and non-cognitive behavioural symptoms. Sporadic AD is multifactorial and genetically complex. While several monogenic mutations cause early-onset AD and gene alleles have been suggested as AD susceptibility factors, the only extensively validated susceptibility gene for late-onset AD is the apolipoprotein E (APOE) epsilon 4 allele. Alleles of the APOE gene do not account for all of the genetic load calculated to be responsible for AD predisposition. Recently, polymorphisms across the neuronal sortilin-related receptor (SORL1) gene were shown to be significantly associated with AD in several cohorts. Here we present the results of our large case-control whole-genome scan at over 500,000 polymorphisms which presents weak evidence for association and potentially narrows the association interval. Copyright (C) 2007 S. Karger AG, Basel.

引用

页码：60 / 64

页数：5

共 9 条

[1] STAGING OF ALZHEIMER-RELATED CORTICAL DESTRUCTION
BRAAK, H
BRAAK, E
BOHL, J
[J]. EUROPEAN NEUROLOGY, 1993, 33 (06) : 403 - 408
[2] A high-density whole-genome association study reveals that APOE is the major susceptibility gene for sporadic late-onset Alzheimer's disease
Coon, Keith D.
Myers, Amanda J.
Craig, David W.
Webster, Jennifer A.
Pearson, John V.
Lince, Diane Hu
Zismann, Victoria L.
Beach, Thomas G.
Leung, Doris
Bryden, Leslie
Halperin, Rebecca F.
Marlowe, Lauren
Kaleem, Mona
Walker, Douglas G.
Ravid, Rivka
Heward, Christopher B.
Rogers, Joseph
Papassotiropoulos, Andreas
Reiman, Eric M.
Hardy, John
Stephan, Dietrich A.
[J]. JOURNAL OF CLINICAL PSYCHIATRY, 2007, 68 (04) : 613 - 618
[3] PREVALENCE OF ALZHEIMERS-DISEASE IN A COMMUNITY POPULATION OF OLDER PERSONS - HIGHER THAN PREVIOUSLY REPORTED
EVANS, DA
FUNKENSTEIN, H
ALBERT, MS
SCHERR, PA
COOK, NR
CHOWN, MJ
HEBERT, LE
HENNEKENS, CH
TAYLOR, JO
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1989, 262 (18): : 2551 - 2556
[4] Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease - A meta-analysis
Farrer, LA
Cupples, LA
Haines, JL
Hyman, B
Kukull, WA
Mayeux, R
Myers, RH
PericakVance, MA
Risch, N
vanDuijn, CM
[J]. JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 1997, 278 (16): : 1349 - 1356
[5] Role of genes and environments for explaining Alzheimer disease
Gatz, M
Reynolds, CA
Fratiglioni, L
Johansson, B
Mortimer, JA
Berg, S
Fiske, A
Pedersen, NL
[J]. ARCHIVES OF GENERAL PSYCHIATRY, 2006, 63 (02) : 168 - 174
[6] Neuropathological diagnostic criteria for Alzheimer's disease
Murayama, S
Saito, Y
[J]. NEUROPATHOLOGY, 2004, 24 (03) : 254 - 260
[7] Pritchard JK, 2000, GENETICS, V155, P945
[8] The neuronal sortilin-related receptor SORL1 is genetically associated with Alzheimer disease
Rogaeva, Ekaterina
Meng, Yan
Lee, Joseph H.
Gu, Yongjun
Kawarai, Toshitaka
Zou, Fanggeng
Katayama, Taiichi
Baldwin, Clinton T.
Cheng, Rong
Hasegawa, Hiroshi
Chen, Fusheng
Shibata, Nobuto
Lunetta, Kathryn L.
Pardossi-Piquard, Raphaelle
Bohm, Christopher
Wakutani, Yosuke
Cupples, L. Adrienne
Cuenco, Karen T.
Green, Robert C.
Pinessi, Lorenzo
Rainero, Innocenzo
Sorbi, Sandro
Bruni, Amalia
Duara, Ranjan
Friedland, Robert P.
Inzelberg, Rivka
Hampe, Wolfgang
Bujo, Hideaki
Song, You-Qiang
Andersen, Olav M.
Willnow, Thomas E.
Graff-Radford, Neill
Petersen, Ronald C.
Dickson, Dennis
Der, Sandy D.
Fraser, Paul E.
Schmitt-Ulms, Gerold
Younkin, Steven
Mayeux, Richard
Farrer, Lindsay A.
St George-Hyslop, Peter
[J]. NATURE GENETICS, 2007, 39 (02) : 168 - 177
[9] ASSOCIATION OF APOLIPOPROTEIN-E ALLELE EPSILON-4 WITH LATE-ONSET FAMILIAL AND SPORADIC ALZHEIMERS-DISEASE
SAUNDERS, AM
STRITTMATTER, WJ
SCHMECHEL, D
GEORGEHYSLOP, PHS
PERICAKVANCE, MA
JOO, SH
ROSI, BL
GUSELLA, JF
CRAPPERMACLACHLAN, DR
ALBERTS, MJ
HULETTE, C
CRAIN, B
GOLDGABER, D
ROSES, AD
[J]. NEUROLOGY, 1993, 43 (08) : 1467 - 1472

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