A founding LRRK2 haplotype shared by Tunisian, US, European and Middle Eastern families with Parkinson's disease

被引：29

作者：

Warren, L. ^{[1
,1
]}

Gibson, R. ^{[2
]}

Ishihara, L. ^{[3
]}

Elango, R. ^{[2
]}

Xue, Z. ^{[1
]}

Akkari, A. ^{[1
]}

Ragone, L.

Pahwa, Rajesh ^{[4
]}

Jankovic, Joseph ^{[5
]}

Nance, Martha

Freemang, Alan ^{[6
]}

Watts, Ray L. ^{[7
]}

Hentati, F. ^{[8
]}

机构：

[1] GlaxoSmithKline Inc, Res & Dev, Res Triangle Pk, NC USA

[2] GlaxoSmithKline Inc, Res & Dev, Greenford UB06 0NN, Middx, England

[3] Univ Cambridge, Dept Publ Hlth & Primary Care, Cambridge CB2 2SR, England

[4] Univ Kansas, Med Ctr, Dept Neurol, Kansas City, KS USA

[5] Baylor Coll Med, Dept Neurol, Houston, TX 77030 USA

[6] Emory Univ, Dept Neurol, Atlanta, GA 30322 USA

[7] Univ Alabama, Dept Neurol, Birmingham, AL 35294 USA

[8] Inst Natl Neurol, Serv Neurol, Tunis 1007, Tunisia

来源：

PARKINSONISM & RELATED DISORDERS | 2008年 / 14卷 / 01期

关键词：

Parkinson's disease; LRRK2; G2019S; founder haplotype;

D O I：

10.1016/j.parkreldis.2007.02.001

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

The Leucine-rich repeat kinase 2 (LRRK2) gene has been identified as a disease susceptibility gene for Parkinson's disease (PID), with G2019 (6055G > A) being the most frequent mutation. This mutation was present in 42% (38/91) of Tunisian families and 2% (1/39) of US families we have studied. A founding haplotype was identified in our data and it is shared by families from Tunisia, US, European and Middle Eastern countries. The most recent common founder of the mutation was dated to 2600 (95% CI: 1950-3850) years ago although additional studies are warranted to ensure an accurate age estimate for this mutation. (C) 2007 Elsevier Ltd. All rights reserved.

引用

页码：77 / 80

页数：4

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