Biotransformation of triptolide by Cunninghamella blakesleana

被引：42

作者：

Ning, LL

Zhan, JX

Qu, GQ

Zhong, L

Guo, HZ

Bi, KS

Guo, D ^{[1
]}

机构：

[1] Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100083, Peoples R China

[2] Peking Univ, Modern Res Ctr Traditional Chinese Med, Beijing 100083, Peoples R China

[3] Shenyang Pharmaceut Univ, Liaoning 110016, Peoples R China

来源：

TETRAHEDRON | 2003年 / 59卷 / 23期

基金：

中国国家自然科学基金;

关键词：

biotransformation triptolide; Cunninghamella blakesleana;

D O I：

10.1016/S0040-4020(03)00605-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Biotransformation of triptolide 1 by Cunninghamella blakesleana (AS 3.970) was carried out. Seven biotransformation products were obtained and four of them were characterized as new compounds. On the basis of their NMR and mass spectral data, their structures were characterized as 5alpha-hydroxytriptolide 2, 1beta-hydroxytriptolide 3, triptodiolide 4, 16-hydroxytriptolide 5, triptolidenol 6, 19alpha-hydroxytriptolide 7 and 19beta-hydroxytriptolide 8. All the new transformed products (2, 3, 7 and 8) were found to exhibit potent in vitro cytotoxicity against some human tumor cell lines. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：4209 / 4213

页数：5

共 12 条

[1]

Chan EWC, 2001, TOXICOL LETT, V122, P81

[2]

DENG F-X, 1985, Acta Botanica Sinica, V27, P516

[3] TUMOR INHIBITORS .74. TRIPTOLIDE AND TRIPDIOLIDE, NOVEL ANTILEUKEMIC DITERPENOID TRIEPOXIDES FROM TRIPTERYGIUM-WILFORDII [J].