Altered MUC1 and MUC2 glycoprotein expression in laryngeal cancer

被引：17

作者：

Jeannon, JP

Stafford, FW

Soames, JV

Wilson, JA

机构：

[1] Sunderland Royal Hosp, Dept Otolaryngol Head & Neck Surg, Sunderland SR4 7TP, Tyne & Wear, England

[2] Univ Newcastle Upon Tyne, Dept Otolaryngol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[3] Univ Newcastle Upon Tyne, Dept Oral Pathol, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

来源：

OTOLARYNGOLOGY-HEAD AND NECK SURGERY | 2001年 / 124卷 / 02期

关键词：

D O I：

10.1067/mhn.2001.112481

中图分类号：

R76 [耳鼻咽喉科学];

学科分类号：

100213 [耳鼻咽喉科学];

摘要：

The purpose of this study was to determine whether mucin expression is altered in laryngeal cancer. MUC1 and MUC2 mucin expression was examined in biopsy specimens from 80 patients that comprised 23 laryngeal dysplasias, 36 laryngeal carcinomas, and 21 normal larynx control specimens. High MUC1 expression was found in all 3 groups (P = 0.689, Fisher exact test). However, significantly higher levels of MUC2 expression were detected in carcinomas compared with dysplasias and control specimens (P = 0.009, Fisher exact test). Altered MUGS expression may be an important step in carcinogenesis in laryngeal cancer.

引用

页码：199 / 202

页数：4

共 13 条

[1]

The MUC2 gene product: a human intestinal mucin [J].