Harnessing transposons for cancer gene discovery

被引：117

作者：

Copeland, Neal G. ^{[1
]}

Jenkins, Nancy A. ^{[1
]}

机构：

[1] Agcy Sci Technol & Res, Genom & Genet Div, Inst Mol & Cell Biol, Singapore 138673, Singapore

来源：

NATURE REVIEWS CANCER | 2010年 / 10卷 / 10期

关键词：

SLEEPING-BEAUTY TRANSPOSITION; GROWTH-FACTOR-RECEPTOR; HEPATITIS-B-VIRUS; CHROMOSOMAL TRANSPOSITION; HEPATOCELLULAR-CARCINOMA; CYTOSINE METHYLATION; SOMATIC MUTAGENESIS; BACULOVIRUS GENOME; ESTROGEN-RECEPTOR; INSERTION SITES;

D O I：

10.1038/nrc2916

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Recently, it has become possible to mobilize the Tc1/mariner transposon, Sleeping Beauty (SB), in mouse somatic cells at frequencies high enough to induce cancer. Tumours result from SB insertional mutagenesis of cancer genes, thus facilitating the identification of the genes and signalling pathways that drive tumour formation. A conditional SB transposition system has also been developed that makes it possible to limit where SB mutagenesis occurs, providing a means to selectively model many types of human cancer. SB mutagenesis has already identified a large collection of known cancer genes in addition to a plethora of new candidate cancer genes and potential drug targets.

引用

页码：696 / 706

页数：11

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