Sequence motifs, polar interactions and conformational changes in helical membrane proteins

被引：196

作者：

Curran, AR ^{[1
]}

Engelman, DM ^{[1
]}

机构：

[1] Yale Univ, Dept Mol Biophys & Biochem, New Haven, CT 06520 USA

来源：

CURRENT OPINION IN STRUCTURAL BIOLOGY | 2003年 / 13卷 / 04期

基金：

英国惠康基金; 美国国家卫生研究院; 美国国家科学基金会;

关键词：

D O I：

10.1016/S0959-440X(03)00102-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The alpha helices of transmembrane proteins interact to form higher order structures. These interactions are frequently mediated by packing motifs (such as GxxxG) and polar residues. Recent structural data have revealed that small sidechains are able to both stabilize helical membrane proteins and allow conformational changes in the structure. The strong interactions involving polar sidechains often contribute to protein misfolding or malfunction.

引用

页码：412 / 417

页数：6

共 51 条

[1] Helix-helix packing and interfacial pairwise interactions of residues in membrane proteins
Adamian, L
Liang, J
[J]. JOURNAL OF MOLECULAR BIOLOGY, 2001, 311 (04) : 891 - 907
[2] Higher-order interhelical spatial interactions in membrane proteins
Adamian, L
Jackups, R
Binkowski, TA
Liang, J
[J]. JOURNAL OF MOLECULAR BIOLOGY, 2003, 327 (01) : 251 - 272
[3] Interhelical hydrogen bonds and spatial motifs in membrane proteins: Polar clamps and serine zippers
Adamian, L
Liang, J
[J]. PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS, 2002, 47 (02) : 209 - 218
[4] Structure and function in bacteriorhodopsin: The effect of the interhelical loops on the protein folding kinetics
Allen, SJ
Kim, JM
Khorana, HG
Lu, H
Booth, PJ
[J]. JOURNAL OF MOLECULAR BIOLOGY, 2001, 308 (02) : 423 - 435
[5] Crystal structure of Escherichia coli MscS, a voltage-modulated and mechanosensitive channel
Bass, RB
Strop, P
Barclay, M
Rees, DC
[J]. SCIENCE, 2002, 298 (5598) : 1582 - 1587
[6] Helix packing in membrane proteins
Bowie, JU
[J]. JOURNAL OF MOLECULAR BIOLOGY, 1997, 272 (05) : 780 - 789
[7] Three-dimensional structure of the bacterial protein-translocation complex SecYEG
Breyton, C
Haase, W
Rapoport, TA
Kühlbrandt, W
Collinson, I
[J]. NATURE, 2002, 418 (6898) : 662 - 665
[8] Activation of the erythropoietin receptor by the gp55-P viral envelope protein is determined by a single amino acid in its transmembrane domain
Constantinescu, SN
Liu, XD
Beyer, W
Fallon, A
Shekar, S
Henis, YI
Smith, SO
Lodish, HF
[J]. EMBO JOURNAL, 1999, 18 (12) : 3334 - 3347
[9] Motifs of serine and threonine can drive association of transmembrane helices
Dawson, JP
Weinger, JS
Engelman, DM
[J]. JOURNAL OF MOLECULAR BIOLOGY, 2002, 316 (03) : 799 - 805
[10] VAL-]ALA MUTATIONS SELECTIVELY ALTER HELIX-HELIX PACKING IN THE TRANSMEMBRANE SEGMENT OF PHAGE M13 COAT PROTEIN
DEBER, CM
KHAN, AR
LI, ZM
JOENSSON, C
GLIBOWICKA, M
WANG, J
[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1993, 90 (24) : 11648 - 11652

← 1 2 3 4 5 6 →