A cellular Trojan horse for delivery of therapeutic nanoparticles into tumors

被引：501

作者：

Choi, Mi-Ran ^{[1
]}

Stanton-Maxey, Katie J. ^{[1
]}

Stanley, Jennifer K. ^{[1
]}

Levin, Carly S. ^{[2
]}

Bardhan, Rizia ^{[2
]}

Akin, Demir ^{[3
]}

Badve, Sunil ^{[4
]}

Sturgis, Jennifer. ^{[5
]}

Robinson, J. Paul ^{[5
]}

Bashir, Rashid ^{[3
,5
]}

Halas, Naomi J. ^{[2
,6
]}

Clare, Susan E. ^{[1
]}

机构：

[1] Indiana Univ, Sch Med, Dept Surg, Indianapolis, IN 46202 USA

[2] Rice Univ, Dept Chem, Houston, TX 77005 USA

[3] Purdue Univ, Birck Nanotechnol Ctr, W Lafayette, IN 47907 USA

[4] Indiana Univ, Sch Med, Dept Pathol & Lab Med, Indianapolis, IN 46202 USA

[5] Purdue Univ, Bindley BioSci Ctr, W Lafayette, IN 47907 USA

[6] Rice Univ, Lab Nanophoton, Houston, TX 77005 USA

来源：

NANO LETTERS | 2007年 / 7卷 / 12期

关键词：

D O I：

10.1021/nl072209h

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Destruction of hypoxic regions within tumors, virtually inaccessible to cancer therapies, may well prevent malignant progression. The tumor's recruitment of monocytes into these regions may be exploited for nanoparticle-based delivery. Monocytes containing therapeutic nanoparticles could serve as "Trojan Horses" for nanoparticle transport into these tumor regions. Here we report the demonstration of several key steps toward this therapeutic strategy: phagocytosis of Au nanoshells, and photoinduced cell death of monocytes/macrophages as isolates and within tumor spheroids.

引用

页码：3759 / 3765

页数：7

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