Mitochondrial regulation of intracellular Ca2+ signaling:: More than just simple Ca2+ buffers

被引：70

作者：

Parekh, AB ^{[1
]}

机构：

[1] Univ Oxford, Dept Physiol, Oxford OX1 3PT, England

来源：

NEWS IN PHYSIOLOGICAL SCIENCES | 2003年 / 18卷

关键词：

D O I：

10.1152/nips.01458.2003

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

Mitochondrial Ca2+ uptake shapes the profile of intracellular Ca2+ signals, both spatially and temporally. In addition, such uptake controls the gating of Ca2+ release and store-operated Ca2+ entry channels, partitions cells into subcellular Ca2+ hotspots, and can result in the release of diffusible signals into the cytosol that subsequently regulate protein function.

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页码：252 / 256

页数：5

相关论文

共 20 条

[1] Mitochondria recycle Ca2+ to the endoplasmic reticulum and prevent the depletion of neighboring endoplasmic reticulum regions [J].

Arnaudeau, S ;

Kelley, WL ;

Walsh, JV ;

Demaurex, N .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (31) :29430-29439

[2] Mitochondrial participation in the intracellular Ca2+ network [J].

Babcock, DF ;

Herrington, J ;

Goodwin, PC ;

Park, YB ;

Hille, B .

JOURNAL OF CELL BIOLOGY, 1997, 136 (04) :833-844

[3] Mitochondria exert a negative feedback on the propagation of intracellular Ca2+ waves in rat cortical astrocytes [J].

Boitier, E ;

Rea, R ;

Duchen, MR .

JOURNAL OF CELL BIOLOGY, 1999, 145 (04) :795-808

[4] Quasi-synaptic calcium signal transmission between endoplasmic reticulum and mitochondria [J].

Csordás, G ;

Thomas, AP ;

Hajnóczky, G .

EMBO JOURNAL, 1999, 18 (01) :96-108

[5] Mitochondrial clearance of cytosolic Ca2+ in stimulated lizard motor nerve terminals proceeds without progressive elevation of mitochondrial matrix [Ca2+] [J].

David, G .

JOURNAL OF NEUROSCIENCE, 1999, 19 (17) :7495-7506

[6] Respiring mitochondria determine the pattern of activation and inactivation of the store-operated Ca2+ current ICRAC [J].

Gilabert, JA ;

Parekh, AB .

EMBO JOURNAL, 2000, 19 (23) :6401-6407

[7] Store-operated Ca2+ entry depends on mitochondrial Ca2+ uptake [J].

Glitsch, MD ;

Bakowski, D ;

Parekh, AB .

EMBO JOURNAL, 2002, 21 (24) :6744-6754

[8] Mitochondria suppress local feedback activation of inositol 1,4,5-trisphosphate receptors by Ca2+ [J].

Hajnóczky, G ;

Hager, R ;

Thomas, AP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (20) :14157-14162

[9] SYNCHRONIZATION OF CALCIUM WAVES BY MITOCHONDRIAL SUBSTRATES IN XENOPUS-LAEVIS OOCYTES [J].

JOUAVILLE, LS ;

ICHAS, F ;

HOLMUHAMEDOV, EL ;

CAMACHO, P ;

LECHLEITER, JD .

NATURE, 1995, 377 (6548) :438-441

[10] Ca2+ homeostasis in the agonist-sensitive internal store:: Functional interactions between mitochondria and the ER measured in situ in intact cells [J].

Landolfi, B ;

Curci, S ;

Debellis, L ;

Pozzan, T ;

Hofer, AM .

JOURNAL OF CELL BIOLOGY, 1998, 142 (05) :1235-1243