Protein oligomerization: How and why

被引：268

作者：

Ali, MH ^{[1
]}

Imperiali, B ^{[1
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY | 2005年 / 13卷 / 17期

关键词：

protein oligomerization; mini-proteins; protein evolution; oligomeric interfaces;

D O I：

10.1016/j.bmc.2005.05.037

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

A large fraction of cellular proteins are oligomeric. Protein oligomerization may often be an advantageous feature from the perspective of protein evolution and has probably evolved by a variety of mechanisms. The study of protein oligomerization may provide insights into the early protein environment and the evolution of modern proteins. Oligomeric mini-proteins, short peptides with discrete protein-like structures, may serve as valuable models for understanding features of protein oligomerization. (c) 2005 Elsevier Ltd. All rights reserved.

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页码：5013 / 5020

页数：8

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