Immunosuppression in renal transplantation: Viral diseases and chronic allograft nephropathy

被引：4

作者：

Salvadori, M ^{[1
]}

Rosati, A ^{[1
]}

Di Maria, L ^{[1
]}

Becherelli, P ^{[1
]}

Moscarelli, L ^{[1
]}

Bandini, S ^{[1
]}

Piperno, R ^{[1
]}

Larti, A ^{[1
]}

Gallo, M ^{[1
]}

Bertoni, E ^{[1
]}

机构：

[1] Careggi Univ Hosp, Renal Unit, Dept Renal Transplantat, I-50139 Florence, Italy

来源：

TRANSPLANTATION PROCEEDINGS | 2005年 / 37卷 / 06期

关键词：

D O I：

10.1016/j.transproceed.2005.06.047

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 [免疫学];

摘要：

Chronic allograft dysfunction after renal transplantation can be ascribed to different causes, among which are viral infections. The aim of this work was to show the various ways by which different kinds of viruses affect transplant structure and function. Polyoma virus is an example of viruses directly affecting the kidney because of a specific tropism to the uroepitelial cells. Cytomegalovirus (CMV) has been chosen both because of the frequency of this infection and because CMV (as other viruses) can produce transplant vascular sclerosis. Finally, we describe hepatitis C virus (HCV) because of its capacity to induce renal lesions independently from chronic allograft nephropathy. Indeed HCV is likely to determine immunologically mediated nephritis in the transplanted kidney as well in the native one.

引用

页码：2500 / 2501

页数：2

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