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Cingulate, Frontal, and Parietal Cortical Dysfunction in Attention-Deficit/Hyperactivity Disorder

被引：232
作者：
Bush, George
机构：
[1] Harvard Univ, Sch Med, Dept Psychiat, Boston, MA 02115 USA
[2] Massachusetts Gen Hosp, Neurosci Div, Dept Psychiat, Boston, MA 02114 USA
[3] Massachusetts Gen Hosp, Benson Henry Inst Mind Body Med, Boston, MA 02114 USA
[4] Harvard Univ, Sch Med, MIT, Charlestown, MA USA
[5] Massachusetts Gen Hosp, Athinoula A Martinos Ctr Funct & Struct Biomed Im, Charlestown, MA USA
来源：
BIOLOGICAL PSYCHIATRY | 2011年 / 69卷 / 12期
基金：
美国国家科学基金会;
关键词：
ADHD; attention; cingulate; cognition; decision; frontal; imaging; parietal; reward; DEFICIT-HYPERACTIVITY DISORDER; FUNCTIONAL MAGNETIC-RESONANCE; EVENT-RELATED FMRI; MULTISOURCE INTERFERENCE TASK; PARENT-CHILD DYADS; ANTERIOR CINGULATE; DOPAMINE TRANSPORTER; INHIBITORY CONTROL; HUMAN BRAIN; COGNITIVE NEUROSCIENCE;
D O I：
10.1016/j.biopsych.2011.01.022
中图分类号：
Q189 [神经科学];
学科分类号：
071006 ;
摘要：
Functional and structural neuroimaging have identified abnormalities of the brain that are likely to contribute to the neuropathophysiology of attention-deficit/hyperactivity disorder (ADHD). In particular, hypofunction of the brain regions comprising the cingulo-frontal-parietal cognitive-attention network have been consistently observed across studies. These are major components of neural systems that are relevant to ADHD, including cognitive/attention networks, motor systems, and reward/feedback-based processing systems. Moreover, these areas interact with other brain circuits that have been implicated in ADHD, such as the "default mode" resting state network. The ADHD imaging data related to cingulo-frontal-parietal network dysfunction will be selectively highlighted here to help facilitate its integration with the other information presented in this special issue. Together, these reviews will help shed light on the neurobiology of ADHD.
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收藏
页码：1160 / 1167
页数：8
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