DC-SIGN and LFA-1: a battle for ligand

被引：59

作者：

Bleijs, DA

Geijtenbeek, TBH

Figdor, CG

van Kooyk, Y

机构：

[1] Free Univ Amsterdam, Med Ctr, Dept Mol Cell Biol, NL-1081 BT Amsterdam, Netherlands

[2] Univ Nijmegen, Med Ctr, Dept Tumor Immunol, NL-6500 HB Nijmegen, Netherlands

来源：

TRENDS IN IMMUNOLOGY | 2001年 / 22卷 / 08期

关键词：

D O I：

10.1016/S1471-4906(01)01974-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The intercellular adhesion molecules (ICAMs) play a prominent role in regulating the migration and activation of both dendritic cells (DCs) and T lymphocytes in the immune system. Recent observations have demonstrated that both leukocyte function-associated molecule 1 (LFA-1) and DC-specific ICAM-grabbing nonintegrin (DC-SIGN), two structurally unrelated adhesion receptors, regulate the function of leukocytes and DCs by binding to the same ICAMs. Here, we focus on the structure-function relationships of DC-SIGN and LFA-1 to obtain an insight into their role in the migration and activation of DCs and T cells in the control of immunity.

引用

页码：457 / 463

页数：7

共 47 条

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