"Clicked" Sugar-Curcumin Conjugate: Modulator of Amyloid-β and Tau Peptide Aggregation at Ultralow Concentrations

被引：71

作者：

Dolai, Sukanta ^{[1
]}

Shi, Wei ^{[3
]}

Corbo, Christopher ^{[2
]}

Sun, Chong ^{[1
]}

Averick, Saadyah ^{[1
]}

Obeysekera, Dinali ^{[1
]}

Farid, Mina ^{[2
]}

Alonso, Alejandra ^{[2
]}

Banerjee, Probal ^{[1
]}

Raja, Krishnaswami ^{[1
]}

机构：

[1] CUNY Coll Staten Isl, Dept Chem, Staten Isl, NY 10314 USA

[2] CUNY Coll Staten Isl, Dept Biol, Staten Isl, NY 10314 USA

[3] Felician Coll, Dept Chem & Phys Sci, Lodi, NJ 07644 USA

来源：

ACS CHEMICAL NEUROSCIENCE | 2011年 / 2卷 / 12期

关键词：

Alzheimer's disease (AD); amyloid-beta; tau peptide; curcumin; click" reaction; antioxidant potential; BLOOD-BRAIN-BARRIER; A-BETA; ALZHEIMERS-DISEASE; PATHOLOGY; OLIGOMERIZATION; DERIVATIVES; INHIBITION; MECHANISM; DRUG;

D O I：

10.1021/cn200088r

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

070307 [化学生物学]; 071010 [生物化学与分子生物学];

摘要：

The synthesis of a water/plasma soluble, noncytotoxic, "clicked" sugar-derivative of curcumin with amplified bioefficacy in modulating amyloid-beta and tau peptide aggregation is presented. Curcumin inhibits amyloid-beta and tau peptide aggregation at micromolar concentrations; the sugar curcumin conjugate inhibits A beta and tau peptide aggregation at concentrations as low as 8 nM and 0.1 n.M, respectively. In comparison to curcumin, this conveniently synthesized Alzheimer's drug candidate is a more powerful antioxidant.

引用

页码：694 / 699

页数：6

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