Hypoxanthine guanine phosphoribosyltransferase activity is related to 6-thioguanine nucleotide concentrations and thiopurine-induced leukopenia in the treatment of inflammatory bowel disease

被引：37

作者：

Ding, Liang ^{[1
]}

Zhang, Fang-bin ^{[2
]}

Liu, Hui ^{[1
]}

Gao, Xiang ^{[2
]}

Bi, Hui-chang ^{[1
]}

Wang, Xue-ding ^{[1
]}

Chen, Bai-li ^{[2
]}

Zhang, Yu ^{[1
]}

Zhao, Li-zi ^{[1
]}

Zhong, Guo-ping ^{[1
]}

Hu, Pin-jin ^{[2
]}

Chen, Min-hu ^{[2
]}

Huang, Ming ^{[1
]}

机构：

[1] Sun Yat Sen Univ, Sch Pharmaceut Sci, Inst Clin Pharmacol, Guangzhou 510006, Guangdong, Peoples R China

[2] Sun Yat Sen Univ, Affiliated Hosp 1, Dept Gastroenterol, Guangzhou 510006, Guangdong, Peoples R China

来源：

INFLAMMATORY BOWEL DISEASES | 2012年 / 18卷 / 01期

关键词：

hypoxanthine guanine phosphoribosyltransferase (HPRT); thiopurine S-methyltransferase (TPMT); 6-thioguanine nucleotides (6-TGNs); thiopurine drug; inflammatory bowel disease (IBD); INOSINE TRIPHOSPHATE PYROPHOSPHATASE; ACUTE LYMPHOBLASTIC-LEUKEMIA; WIDELY USED METHODS; S-METHYLTRANSFERASE; CROHNS-DISEASE; GENETIC-POLYMORPHISM; DRUG-INTERACTION; METABOLITE CONCENTRATIONS; HYDROLYSIS CONTRIBUTE; LIQUID-CHROMATOGRAPHY;

D O I：

10.1002/ibd.21676

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

100201 [内科学];

摘要：

Background: Thiopurine drugs are widely used in the treatment of inflammatory bowel disease (IBD). The polymorphic enzyme thiopurine S-methyltransferase (TPMT) is of importance for thiopurine metabolism and adverse events occurrence. The role of other thiopurine-metabolizing enzymes is less well known. This study investigated the effects of TPMT and hypoxanthine guanine phosphoribosyltransferase (HPRT) activities on 6-thioguanine nucleotides (6-TGNs) concentrations and thiopurine-induced leukopenia in patients with IBD.

引用

页码：63 / 73

页数：11

共 74 条

[1]

ADLER DJ, 1990, AM J GASTROENTEROL, V85, P717

[2]

Prospective evaluation of the pharmacogenetics of azathioprine in the treatment of inflammatory bowel disease [J].