HIF, a missing link between metabolism and cancer

被引：47

作者：

Esteban, MA ^{[1
]}

Maxwell, PH ^{[1
]}

机构：

[1] Univ London Imperial Coll Sci & Technol, Hammersmith Hosp, London W12 0NN, England

来源：

NATURE MEDICINE | 2005年 / 11卷 / 10期

关键词：

D O I：

10.1038/nm1005-1047

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mutations in metabolic enzymes lead to changes in stability of HIF, highlighting the connection between metabolism and cancer.

引用

页码：1047 / 1048

页数：2

共 11 条

[1] A role for mitochondrial enzymes in inherited neoplasia and beyond [J].

Eng, C ;

Kiuru, M ;

Fernandez, MJ ;

Aaltonen, LA .

NATURE REVIEWS CANCER, 2003, 3 (03) :193-202

[2] Energy boost: The Warburg effect returns in a new theory of cancer [J].

Garber, K .

JOURNAL OF THE NATIONAL CANCER INSTITUTE, 2004, 96 (24) :1805-1806

[3] Hypoxia - A key regulatory factor in tumour growth [J].

Harris, AL .

NATURE REVIEWS CANCER, 2002, 2 (01) :38-47

[4] HIF overexpression correlates with biallelic loss of fumarate hydratase in renal cancer: Novel role of fumarate in regulation of HIF stability [J].

Isaacs, JS ;

Jung, YJ ;

Mole, DR ;

Lee, S ;

Torres-Cabala, C ;

Chung, YL ;

Merino, M ;

Trepel, J ;

Zbar, B ;

Toro, J ;

Ratcliffe, PJ ;

Linehan, WM ;

Neckers, L .

CANCER CELL, 2005, 8 (02) :143-153

[5] Neuronal apoptosis linked to EgIN3 prolyl hydroxylase and familial pheochromocytoma genes: Developmental culling and cancer [J].

Lee, S ;

Nakamura, E ;

Yang, HF ;

Wei, WY ;

Linggi, MS ;

Sajan, MP ;

Farese, RV ;

Freeman, RS ;

Carter, BD ;

Kaelin, WG ;

Schlisio, S .

CANCER CELL, 2005, 8 (02) :155-167

[6] The tumour suppressor protein VHL targets hypoxia-inducible factors for oxygen-dependent proteolysis [J].

Maxwell, PH ;

Wiesener, MS ;

Chang, GW ;

Clifford, SC ;

Vaux, EC ;

Cockman, ME ;

Wykoff, CC ;

Pugh, CW ;

Maher, ER ;

Ratcliffe, PJ .

NATURE, 1999, 399 (6733) :271-275

[7] Accumulation of Krebs cycle intermediates and over-expression of HIF1α in tumours which result from germline FH and SDH mutations [J].

Pollard, PJ ;

Brière, JJ ;

Alam, NA ;

Barwell, J ;

Barclay, E ;

Wortham, NC ;

Hunt, T ;

Mitchell, M ;

Olpin, S ;

Moat, SJ ;

Hargreaves, IP ;

Heales, SJ ;

Chung, YL ;

Griffiths, JR ;

Dalgleish, A ;

McGrath, JA ;

Gleeson, MJ ;

Hodgson, SV ;

Poulsom, R ;

Rustin, P ;

Tomlinson, IPM .

HUMAN MOLECULAR GENETICS, 2005, 14 (15) :2231-2239

[8] Oxygen sensing by HIF hydroxylases [J].

Schofield, CJ ;

Ratcliffe, PJ .

NATURE REVIEWS MOLECULAR CELL BIOLOGY, 2004, 5 (05) :343-354

[9] Succinate links TCA cycle dysfunction to oncogenesis by inhibiting HIF-α prolyl hydroxylase [J].

Selak, MA ;

Armour, SM ;

MacKenzie, ED ;

Boulahbel, H ;

Watson, DG ;

Mansfield, KD ;

Pan, Y ;

Simon, MC ;

Thompson, CB ;

Gottlieb, E .

CANCER CELL, 2005, 7 (01) :77-85

[10] Targeting HIF-1 for cancer therapy [J].

Semenza, GL .

NATURE REVIEWS CANCER, 2003, 3 (10) :721-732

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