Pro-healing potential of hemin: An inducer of heme oxygenase-1

被引：26

作者：

Ahanger, Azad A. ^{[1
]}

Prawez, Shahid ^{[1
]}

Leo, Marie Dennis Marcus ^{[1
]}

Kathirvel, Kandaswamy ^{[1
]}

Kumar, Dinesh ^{[1
]}

Tandan, Surendra K. ^{[1
]}

Malik, Jitendra K. ^{[1
]}

机构：

[1] Indian Vet Res Inst, Div Pharmacol & Toxicol, Izatnagar 243122, Uttar Pradesh, India

来源：

EUROPEAN JOURNAL OF PHARMACOLOGY | 2010年 / 645卷 / 1-3期

关键词：

Heme oxygenase; Hemin; Wound healing; CARBON-MONOXIDE; ANTIOXIDANT; MECHANISMS; EXPRESSION; RESISTANCE; BILIRUBIN; TOXICITY; PREVENTS; STRESS; TISSUE;

D O I：

10.1016/j.ejphar.2010.06.048

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Hemin induces heme oxygenase (HO), an enzyme which degrades heme in a rate-limiting manner and has an important role in cellular protection against oxidative stress and apoptosis. This HO inducer may be of potential therapeutic value in wound healing and inflammation. To identify the beneficial activity of HO vis a vis wound healing, hemin was used as inducer of HO in rats using a full-thickness cutaneous wound model. Hemin treatment increased cellular proliferation and collagen synthesis as evidenced by increase in wound contraction and hydroxyproline and glucosamine contents. mRNA expression of cytokines endorsed fast healing as was indicated by inhibition of pro-inflammatory cytokines such as ICAM-1 and TNF-alpha and up-regulation of anti-inflammatory cytokine IL-10. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：165 / 170

页数：6

共 36 条

[1] Pharmacological and clinical aspects of heme oxygenase [J].

Abraham, Nader G. ;

Kappas, Attallah .

PHARMACOLOGICAL REVIEWS, 2008, 60 (01) :79-127

[2] 2 GENES CONTRIBUTE TO DIFFERENT EXTENTS TO THE HEME OXYGENASE ENZYME-ACTIVITY MEASURED IN CULTURED HUMAN SKIN FIBROBLASTS AND KERATINOCYTES - IMPLICATIONS FOR PROTECTION AGAINST OXIDANT STRESS [J].

APPLEGATE, LA ;

NOEL, A ;

VILE, G ;

FRENK, E ;

TYRRELL, RM .

PHOTOCHEMISTRY AND PHOTOBIOLOGY, 1995, 61 (03) :285-291

[3] Heme oxygenase-mediated resistance to oxygen toxicity in hamster fibroblasts [J].

Dennery, PA ;

Sridhar, KJ ;

Lee, CS ;

Wong, HE ;

Shokoohi, V ;

Rodgers, PA ;

Spitz, DR .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (23) :14937-14942

[4] Oxygen toxicity and iron accumulation in the lungs of mice lacking heme oxygenase-2 [J].

Dennery, PA ;

Spitz, DR ;

Yang, G ;

Tatarov, A ;

Lee, CS ;

Shegog, ML ;

Poss, KD .

JOURNAL OF CLINICAL INVESTIGATION, 1998, 101 (05) :1001-1011

[5] Differences in basal and hyperoxia-associated HO expression in oxidant-resistant hamster fibroblasts [J].

Dennery, PA ;

Wong, HE ;

Sridhar, KJ ;

Rodgers, PA ;

Sim, JE ;

Spitz, DR .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 1996, 271 (04) :L672-L679

[6]

Deramaudt BMJM, 1998, J CELL BIOCHEM, V68, P121, DOI 10.1002/(SICI)1097-4644(19980101)68:1<121::AID-JCB12>3.0.CO

[7]

2-K

[8] Heme oxygenase-1 in tissue pathology -: The yin and yang [J].

Dong, Z ;

Lavrovsky, Y ;

Venkatachalam, MA ;

Roy, AK .

AMERICAN JOURNAL OF PATHOLOGY, 2000, 156 (05) :1485-1488

[9] Haem oxygenase-1 prevents cell death by regulating cellular iron [J].

Ferris, CD ;

Jaffrey, SR ;

Sawa, A ;

Takahashi, M ;

Brady, SD ;

Barrow, RK ;

Tysoe, SA ;

Wolosker, H ;

Barañano, DE ;

Doré, S ;

Poss, KD ;

Snyder, SH .

NATURE CELL BIOLOGY, 1999, 1 (03) :152-157

[10] Protective effect of hemin against cadmium-induced testicular damage in rats [J].

Fouad, Amr A. ;

Qureshi, Habib A. ;

Al-Sultan, Ali Ibrahim ;

Yacoubi, Mohamed T. ;

Ali, Abdellah Abusrie .

TOXICOLOGY, 2009, 257 (03) :153-160

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