Determination of formaldehyde in urine by headspace gas chromatography

被引：104

作者：

Takeuchi, Akito

Takigawa, Tomoko

Abe, Mikiko

Kawai, Toshio

Endo, Yoko

Yasugi, Tomojiro

Endo, Ginji

Ogino, Keiki

机构：

[1] Okayama Univ, Grad Sch Med Dent & Pharmaceut Sci, Dept Publ Hlth, Okayama 7008558, Japan

[2] Osaka City Univ, Sch Med, Dept Anat & Cellbiol, Abeno Ku, Osaka 5458585, Japan

[3] Osaka Occupat Hlth Serv Ctr, Nishi Ku, Osaka 5500001, Japan

[4] Japan Labour Hlth & Welfare Org, Tokyo Rosai Hosp, Ctr Res Occupat Poisoning, Ohta Ku, Tokyo 1430013, Japan

[5] Chugoku & Shikoku Reg Safety & Hlth Serv Ctr, Nishi Ku, Hiroshima 7330003, Japan

[6] Osaka City Univ, Sch Med, Dept Prevent Med & Environm Hlth, Abeno Ku, Osaka 5458585, Japan

来源：

BULLETIN OF ENVIRONMENTAL CONTAMINATION AND TOXICOLOGY | 2007年 / 79卷 / 01期

关键词：

formaldehyde; headspace analysis; gas chromatography; human urine; O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine;

D O I：

10.1007/s00128-007-9172-0

中图分类号：

X [环境科学、安全科学];

学科分类号：

08 [工学]; 0830 [环境科学与工程];

摘要：

Formaldehyde is a carcinogen to which humans are exposed daily, but few methods are available to quantify formaldehyde in biological samples. We developed a simple, sensitive and rapid technique for the quantification of formaldehyde in urine by derivatization with O-(2,3,4,5,6-pentafluorobenzyl)hydroxylamine, using a headspace sampler coupled to a gas chromatograph equipped with an electron capture detector. The detection limit was 1.08 mu g/L. The overall recovery of formaldehyde spiked in urine was 99%. The concentration of formaldehyde in urine obtained from healthy volunteers ranged from 56.85 to 144.57 mu g/L. This method can be used successfully to measure formaldehyde in urine.

引用

页码：1 / 4

页数：4

共 12 条

[1]

O-(2,3,4,5,6-PENTAFLUOROPHENYL)METHYLHYDROXYLAMINE HYDROCHLORIDE - A VERSATILE REAGENT FOR THE DETERMINATION OF CARBONYL-CONTAINING COMPOUNDS [J].