Drugs for Hepatitis C: Unlocking a New Mechanism of Action

被引:15
作者
Bell, Thomas W. [1 ]
机构
[1] Univ Nevada, Dept Chem, Reno, NV 89557 USA
关键词
antiviral drugs; chemical genetics; drug symmetry; hepatitis C; NS5A inhibitors; DISCOVERY; PROTEASE; INHIBITORS;
D O I
10.1002/cmdc.201000334
中图分类号
R914 [药物化学];
学科分类号
100705 [微生物与生化药学];
摘要
引用
收藏
页码:1663 / 1665
页数:3
相关论文
共 17 条
[1]
*AM ASS STUD LIV D, 2008, BMS790052 AM ASS STU
[2]
Molecular recognition of protein-ligand complexes: Applications to drug design [J].
Babine, RE ;
Bender, SL .
CHEMICAL REVIEWS, 1997, 97 (05) :1359-1472
[3]
HIV-1 protease: mechanism and drug discovery [J].
Brik, A ;
Wong, CH .
ORGANIC & BIOMOLECULAR CHEMISTRY, 2003, 1 (01) :5-14
[4]
Diphenylcarboxam ides as Inhibitors of HCV Non-Structural Protein NS5a [J].
Carter, Malcolm ;
Baxter, Bob ;
Bushnell, David ;
Cockerill, Stuart ;
Chapman, Jo ;
Fram, Sally ;
Goulding, Emma ;
Lockyer, Mike ;
Mathews, Neil ;
Najarro, Pilar ;
Rupassara, Dilupa ;
Salter, James ;
Thomas, Elaine ;
Wheelhouse, Chris ;
Borger, Jessica ;
Powell, Kenneth .
ANTIVIRAL RESEARCH, 2010, 86 (01) :A19-A19
[5]
Synthesis and SAR of piperazinyl-N-phenylbenzamides as inhibitors of hepatitis C virus RNA replication in cell culture [J].
Conte, Immacolata ;
Giuliano, Claudio ;
Ercolani, Caterina ;
Narjes, Frank ;
Koch, Uwe ;
Rowley, Michael ;
Altamura, Sergio ;
De Francesco, Raffaele ;
Neddermann, Petra ;
Migliaccio, Giovanni ;
Stansfield, Ian .
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2009, 19 (06) :1779-1783
[6]
DRISCOLL JS, 2002, ANTIVIRAL DRUGS, pCH2
[7]
Identification of Hepatitis C Virus NS5A Inhibitors [J].
Lemm, Julie A. ;
O'Boyle, Donald, II ;
Liu, Mengping ;
Nower, Peter T. ;
Colonno, Richard ;
Deshpande, Milind S. ;
Snyder, Lawrence B. ;
Martin, Scott W. ;
Laurent, Denis R. St. ;
Serrano-Wu, Michael H. ;
Romine, Jeffrey L. ;
Meanwell, Nicholas A. ;
Gao, Min .
JOURNAL OF VIROLOGY, 2010, 84 (01) :482-491
[8]
Development of novel therapies for hepatitis C [J].
Lemon, Stanley M. ;
McKeating, Jane A. ;
Pietschmann, Thomas ;
Frick, David N. ;
Glenn, Jeffrey S. ;
Tellinghuisen, Timothy L. ;
Symons, Julian ;
Furman, Phillip A. .
ANTIVIRAL RESEARCH, 2010, 86 (01) :79-92
[9]
Replication of subgenomic hepatitis C virus RNAs in a hepatoma cell line [J].
Lohmann, V ;
Körner, F ;
Koch, JO ;
Herian, U ;
Theilmann, L ;
Bartenschlager, R .
SCIENCE, 1999, 285 (5424) :110-113
[10]
Progress towards the Discovery and Development of Specifically Targeted inhibitors of Hepatitis C Virus [J].
Meanwell, Nicholas A. ;
Kadow, John F. ;
Scola, Paul M. .
ANNUAL REPORTS IN MEDICINAL CHEMISTRY, VOL 44, 2009, 44 :397-440