Effects of benzodiazepines on explicit memory in a paediatric surgery setting

被引:27
作者
Buffett-Jerrott, SE
Stewart, SH
Finley, GA
Loughlan, HL
机构
[1] Bedford Sackville Community Mental Hlth IWK, Lower Sackville, NS B4C 2J3, Canada
[2] Dalhousie Univ, Dept Psychol, Life Sci Ctr, Halifax, NS B3H 4J1, Canada
[3] IWK Hlth Ctr, Dept Pediat Anesthesia, Halifax, NS B3J 3G9, Canada
关键词
benzodiazepine; explicit memory; midazolam; surgery;
D O I
10.1007/s00213-003-1429-7
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Rationale. Many laboratory-based studies indicate that benzodiazepines impair explicit memory performance, increase sedation, and impair attention. Objectives. The present study was designed to extend prior lab-based findings to an applied setting in which the amnestic effects of benzodiazepines may be beneficial for users. In addition, the study extended the previous adult-focused research by examining the cognitive effects of benzodiazepines in children. Methods. The present study examined the use of a specific benzodiazepine (midazolam) as a premedicant among 40 children aged 4-6 years old having ear tube (myringotomy) surgery, who were randomly assigned to receive midazolam or placebo. Results. Consistent with previous studies, the results indicated that midazolam causes significant amnesia on a cued recall task. In addition, free recall for post-drug events were also impaired by midazolam relative to placebo, indicating that benzodiazepine-induced amnesia occurs even for highly salient information. Conclusions. Overall, it appears that benzodiazepines do impair memory in a pediatric population. This amnesia was not secondary to the inattention and sedation also caused by midazolam administration. The theoretical and clinical implications of these findings are discussed, as are potential future studies.
引用
收藏
页码:377 / 386
页数:10
相关论文
共 36 条
[1]   PSYCHOPHARMACOLOGICAL ANALYSIS OF IMPLICIT AND EXPLICIT MEMORY - A STUDY WITH LORAZEPAM AND THE BENZODIAZEPINE ANTAGONIST FLUMAZENIL [J].
BISHOP, KI ;
CURRAN, HV .
PSYCHOPHARMACOLOGY, 1995, 121 (02) :267-278
[2]   ALPRAZOLAM AND LORAZEPAM EFFECTS ON MEMORY ACQUISITION AND RETRIEVAL-PROCESSES [J].
BLOCK, RI ;
BERCHOU, R .
PHARMACOLOGY BIOCHEMISTRY AND BEHAVIOR, 1984, 20 (02) :233-241
[3]   A COMPARISON BETWEEN TRANSIENT AMNESIAS INDUCED BY 2 DRUGS (DIAZEPAM OR LORAZEPAM) AND AMNESIA OF ORGANIC-ORIGIN [J].
BROWN, J ;
LEWIS, V ;
BROWN, M ;
HORN, G ;
BOWES, JB .
NEUROPSYCHOLOGIA, 1982, 20 (01) :55-70
[4]   A further examination of the time-dependent effects of oxazepam and lorazepam on implicit and explicit memory [J].
Buffett-Jerrott, SE ;
Stewart, SH ;
Teehan, MD .
PSYCHOPHARMACOLOGY, 1998, 138 (3-4) :344-353
[5]   Cognitive and sedative effects of benzodiazepine use [J].
Buffett-Jerrott, SE ;
Stewart, SH .
CURRENT PHARMACEUTICAL DESIGN, 2002, 8 (01) :45-58
[6]   An examination of differences in the time course of oxazepam's effects on implicit vs explicit memory [J].
Buffett-Jerrott, SE ;
Stewart, SH ;
Bird, S ;
Teehan, MD .
JOURNAL OF PSYCHOPHARMACOLOGY, 1998, 12 (04) :338-347
[7]   Clinical assessment of sustained attention in preschoolers [J].
Corkum, V ;
Byrne, JM ;
Ellsworth, C .
CHILD NEUROPSYCHOLOGY, 1995, 1 (01) :3-18
[8]   COMPARATIVE AMNESIC AND SEDATIVE EFFECTS OF LORAZEPAM AND OXAZEPAM IN HEALTHY-VOLUNTEERS [J].
CURRAN, HV ;
GORENSTEIN, C ;
LADER, M .
JOURNAL OF PSYCHOPHARMACOLOGY, 1993, 7 (03) :249-256
[9]   DIFFERENTIAL-EFFECTS OF LORAZEPAM AND OXAZEPAM ON PRIMING [J].
CURRAN, HV ;
GORENSTEIN, C .
INTERNATIONAL CLINICAL PSYCHOPHARMACOLOGY, 1993, 8 (01) :37-42
[10]   TRANQUILIZING MEMORIES - A REVIEW OF THE EFFECTS OF BENZODIAZEPINES ON HUMAN-MEMORY [J].
CURRAN, HV .
BIOLOGICAL PSYCHOLOGY, 1986, 23 (02) :179-213