Application of Alpha7 Nicotinic Acetylcholine Receptor Agonists in Inflammatory Diseases: An Overview

被引：45

作者：

Marrero, Mario B. ^{[1
]}

Bencherif, Merouane ^{[2
]}

Lippiello, Patrick M. ^{[2
]}

Lucas, Rudolf ^{[1
]}

机构：

[1] Med Coll Georgia, Vasc Biol Ctr, Dept Pharmacol & Toxicol, Augusta, GA 30912 USA

[2] Targacept Inc, Preclin Res, Winston Salem, NC USA

来源：

PHARMACEUTICAL RESEARCH | 2011年 / 28卷 / 02期

关键词：

inflammation; alpha7 nicotinic acetylcholine receptor agonists; cholinergic anti-inflammatory pathway; Jak/STAT pathway; MEDIATED NEUROPROTECTION; ACTIVATION;

D O I：

10.1007/s11095-010-0283-7

中图分类号：

O6 [化学];

学科分类号：

070301 [无机化学];

摘要：

Inflammatory disorders are characterized by the influx of immune cells into the vascular wall of veins and/or arteries in response to stimuli such as oxidized-LDL and various pathogens. These factors stimulate the local production of pro-inflammatory cytokines by macrophages and other cells that promote various inflammatory diseases such as atherosclerosis, Crohn's, Alzheimer's and diabetes. Numerous cytokines play a significant role in this process, though tumor necrosis factor (TNF) and various interleukins are thought to be among the most important regulators. These proinflammatory cytokines promote the above-described diseases by inducing endothelial cell dysfunction. In this brief commentary we will discuss some of the latest advances and discoveries in the treatment of these inflammatory diseases, making use of alpha7 nicotinic acetylcholine receptor (alpha7 nAChR) agonists.

引用

页码：413 / 416

页数：4

共 10 条

[1]

Activation of the cholinergic anti-inflammatory pathway reduces NF-κB activation, blunts TNF-α production, and protects against splanchnic artery occlusion shock [J].

Altavilla, D ;

Guarini, S ;

Bitto, A ;

Mioni, C ;

Giuliani, D ;

Bigiani, A ;

Squadrito, G ;

Minutoli, L ;

Venuti, FS ;

Messineo, F ;

De Meo, V ;

Bazzani, C ;

Squadrito, F .

SHOCK, 2006, 25 (05) :500-506

[2]

Long-lasting cognitive improvement with nicotinic receptor agonists: mechanisms of pharmacokinetic-pharmacodynamic discordance [J].

Buccafusco, JJ ;

Letchworth, SR ;

Bencherif, M ;

Lippiello, PM .

TRENDS IN PHARMACOLOGICAL SCIENCES, 2005, 26 (07) :352-360

[3]

An α7 Nicotinic Acetylcholine Receptor-Selective Agonist Reduces Weight Gain and Metabolic Changes in a Mouse Model of Diabetes [J].

Marrero, Mario B. ;

Lucas, Rudolf ;

Salet, Christina ;

Hauser, Terry A. ;

Mazurov, Anatoly ;

Lippiello, Patrick M. ;

Bencherif, Merouane .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2010, 332 (01) :173-180

[4]

Convergence of alpha 7 nicotinic acetylcholine receptor-activated pathways for anti-apoptosis and anti-inflammation: Central role for JAK2 activation of STAT3 and NF-κB [J].

Marrero, Mario B. ;

Bencherif, Merouane .

BRAIN RESEARCH, 2009, 1256 :1-7

[5]

Cholinergic stimulation blocks endothelial cell activation and leukocyte recruitment during inflammation [J].

Saeed, RW ;

Varma, S ;

Peng-Nemeroff, T ;

Sherry, B ;

Balakhaneh, D ;

Huston, J ;

Tracey, KJ ;

Al-Abed, Y ;

Metz, CN .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (07) :1113-1123

[6]

Shaw S, 2003, J NEUROSCI, V23, P11224

[7]

Janus kinase 2, an early target of α7 nicotinic acetylcholine receptor-mediated neuroprotection against Aβ-(1-42) amyloid [J].

Shaw, S ;

Bencherif, M ;

Marrero, MB .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (47) :44920-44924

[8]

Requisite Role of the Cholinergic α7 Nicotinic Acetylcholine Receptor Pathway in Suppressing Gram-Negative Sepsis-Induced Acute Lung Inflammatory Injury [J].

Su, Xiao ;

Matthay, Michael A. ;

Malik, Asrar B. .

JOURNAL OF IMMUNOLOGY, 2010, 184 (01) :401-410

[9]

Effect of Nicotine on Advanced Glycation End Product-Induced Immune Response in Human Monocytes [J].

Takahashi, Hideo Kohka ;

Liu, Keyue ;

Wake, Hidenori ;

Mori, Shuji ;

Zhang, Jiyong ;

Liu, Rui ;

Yoshino, Tadashi ;

Nishibori, Masahiro .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2010, 332 (03) :1013-1021

[10]

Nicotinic acetylcholine receptor α7 subunit is an essential regulator of inflammation [J].

Wang, H ;

Yu, M ;

Ochani, M ;

Amella, CA ;

Tanovic, M ;

Susarla, S ;

Li, JH ;

Wang, HC ;

Yang, H ;

Ulloa, L ;

Al-Abed, Y ;

Czura, CJ ;

Tracey, KJ .

NATURE, 2003, 421 (6921) :384-388

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