Effect of modafinil on cerebral blood flow of anaesthetised rats -: Comparison with amphetamine

被引：12

作者：

Florence, G ^{[1
]}

Bonnier, R ^{[1
]}

Plagnes, D ^{[1
]}

Piérard, C ^{[1
]}

Satabin, P ^{[1
]}

Pérès, M ^{[1
]}

Lagarde, D ^{[1
]}

机构：

[1] Serv Sante Armees, Inst Med Aerosp, Dept Physiol Aerosp, F-91223 Bretigny Sur Orge, France

来源：

EXPERIMENTAL BRAIN RESEARCH | 2000年 / 135卷 / 04期

关键词：

cerebral blood flow; laser-Doppler flowmetry; modafinil; amphetamine; rat;

D O I：

10.1007/s002210000555

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This experiment compares the cardio- and cerebrovascular effects of modafinil and amphetamine administered to rats. Injections of 300 mg/kg and 606 mg/kg modafinil i.p. had no major effect. Ln contrast. injection of D-amphetamine sulfate (5 mg/kg i.v.) induced a long-lasting rise in heart rate and in mean arterial brood pressure (MABP). Amphetamine administration also elicited a 70-min-long increase in cortical cerebral blood flow which was proportional to the increase in MABP. We conclude that, contrary to amphetamine, modafinil has no effect on perfusion in the cerebral cortex of anaesthetised rats.

引用

页码：552 / 556

页数：5

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