Genetic interaction of CTLA-4 with HLA-DR15 in multiple sclerosis patients

被引：34

作者：

Alizadeh, M

Babron, MC

Birebent, B

Matsuda, F

Quelvennec, E

Liblau, R

Cournu-Rebeix, I

Momigliano-Richiardi, P

Sequeiros, J

Yaouanq, J

Genin, E

Vasilescu, A

Bougerie, H

Trojano, M

Silva, BM

Maciel, P

Clerget-Darpoux, F

Clanet, M

Edan, G

Fontaine, B

Semana, G

机构：

[1] Etablissment Francais Sang, Immunogenet Lab, Fac Med, F-35000 Rennes, France

[2] Lab Univ Immunol, UPRES EA 1257, IFR 97, Rennes, France

[3] French Grp MS Genet, Paris, France

[4] INSERM, U535, Paris, France

[5] Ctr Natl Genotype, Evry, France

[6] INSERM, U563, Toulouse, France

[7] Hop Purpan, Serv Neurol, Toulouse, France

[8] Grp Hosp Pitie Salpetriere, Federat Neurol, F-75634 Paris, France

[9] Grp Hosp Pitie Salpetriere, INSERM U546, F-75634 Paris, France

[10] Eastern Piedmont Univ, Dept Med Sci, Novara, Italy

[11] Eastern Piedmont Univ, IRCAD, Novara, Italy

[12] Italian Grp MS Genet, Bari, Italy

[13] Univ Porto, IBMC, UniGENe, P-4100 Oporto, Portugal

[14] Portuguese Grp MS Genet, Oporto, Portugal

[15] Hop Pontchaillou, Neurol Clin, Rennes, France

[16] Univ Bari, Dept Neurol & Psychiat, Bari, Italy

[17] Univ Porto, ICBAS, Dept Patol & Imunol Mol, Immunogenet Lab, P-4100 Oporto, Portugal

[18] Univ Minho, Braga, Portugal

来源：

ANNALS OF NEUROLOGY | 2003年 / 54卷 / 01期

关键词：

D O I：

10.1002/ana.10617

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Multiple sclerosis is a chronic inflammatory disease of the central nervous system with a genetic component. Until now, the more consistent association with the disease is found with the major histocompatibility complex, especially HLA-DRB1*1501-DQB1*0602 haplotype. In this report, we demonstrate the interaction of Cytotoxic T Lymphocyte-associated antigen 4 (CTLA-4 [CD152]) gene with DRB1*15 haplotype in multiple sclerosis genetic susceptibility. Our data were obtained from two European independent family-based studies including 610 multiple sclerosis family trios.

引用

页码：119 / 122

页数：4

共 20 条

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