Hypothesis: spring-loaded boomerang mechanism of influenza hemagglutinin-mediated membrane fusion

被引：73

作者：

Tamm, LK ^{[1
]}

机构：

[1] Univ Virginia, Hlth Sci Ctr, Dept Mol Physiol & Biol Phys, Charlottesville, VA 22908 USA

来源：

BIOCHIMICA ET BIOPHYSICA ACTA-BIOMEMBRANES | 2003年 / 1614卷 / 01期

关键词：

membrane fusion; fusion peptide; hemagglutinin; structure; folding; energetic; lipid-protein interaction;

D O I：

10.1016/S0005-2736(03)00159-7

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Substantial progress has been made in recent years to augment the current understanding of structures and interactions that promote viral membrane fusion. This progress is reviewed with a particular emphasis on recently determined structures of viral fusion domains and their interactions with lipid membranes. The results from the different structural and thermodynamic experimental approaches are synthesized into a new proposed mechanism, termed the "spring-loaded boomerang" mechanism of membrane fusion, which is presented here as a hypothesis. (C) 2003 Elsevier B.V. All rights reserved.

引用

页码：14 / 23

页数：10

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