A dispersion model for the hepatic uptake and elimination of 2,3,7,8-tetrachlorodibenzo-p-dioxin

被引：7

作者：

Banks, HT ^{[1
]}

Musante, CJ

Tran, HT

机构：

[1] N Carolina State Univ, Ctr Res Sci Computat, Raleigh, NC 27695 USA

[2] N Carolina State Univ, Dept Math, Raleigh, NC 27695 USA

来源：

MATHEMATICAL AND COMPUTER MODELLING | 1998年 / 28卷 / 01期

关键词：

physiologically-based pharmacokinetic (PBPK) model; 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD); liver transport models; nonlinear partial differential equations; delay equations;

D O I：

10.1016/S0895-7177(98)00077-6

中图分类号：

TP39 [计算机的应用];

学科分类号：

081203 ; 0835 ;

摘要：

A convection-dispersion model for the uptake and elimination of 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) in the liver is presented. The model is adapted from the general dispersion model of Roberts and Rowland and includes the dynamics of TCDD interaction with two intracellular proteins, the Ah receptor and cytochrome P450 IA2. A "well-mixed" compartment was added to describe the venous blood concentration of TCDD. The result is a nonlinear system of seven coupled partial and ordinary differential equations with time delays. (C) 1998 Elsevier Science Ltd. All rights reserved.

引用

页码：9 / 29

页数：21

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