Towards a point-of-care test for active tuberculosis: obstacles and opportunities

被引：151

作者：

McNerney, Ruth ^{[1
]}

Daley, Peter ^{[2
]}

机构：

[1] London Sch Hyg & Trop Med, Dept Pathogen Mol Biol, London WC1E 7HT, England

[2] Mem Univ Newfoundland, Hlth Sci Ctr, St John, NF A1B 3V6, Canada

来源：

NATURE REVIEWS MICROBIOLOGY | 2011年 / 9卷 / 03期

基金：

英国惠康基金;

关键词：

ELECTRONIC-NOSE TECHNOLOGY; COMMERCIAL URINARY LIPOARABINOMANNAN; MEDIATED ISOTHERMAL AMPLIFICATION; XPERT MTB/RIF ASSAY; MYCOBACTERIUM-TUBERCULOSIS; PULMONARY TUBERCULOSIS; RAMAN-SPECTROSCOPY; RIFAMPICIN-RESISTANCE; DEVELOPING-COUNTRIES; DIAGNOSTIC-ACCURACY;

D O I：

10.1038/nrmicro2521

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Limited access to diagnostic services and the poor performance of current tests result in a failure to detect millions of tuberculosis cases each year. An accurate test that could be used at the point of care to allow faster initiation of treatment would decrease death rates and could reduce disease transmission. Previous attempts to develop such a test have failed, and success will require the marriage of biomarkers that are highly predictive for the disease with innovative technology that is reliable and affordable. Here, we review the status of research into point-of-care tests for active tuberculosis and discuss barriers to the development of such diagnostic tests.

引用

页码：204 / 213

页数：10

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