Expedient synthesis of 2-chloroethylnitrososulfamides (CENS) via the decarboxylative reopening of sulfamoyloxazolidinones

被引：36

作者：

Abdaoui, M ^{[1
]}

Dewynter, G ^{[1
]}

Montero, JL ^{[1
]}

机构：

[1] UNIV MONTPELLIER 2,CNRS,LAB CHIM BIOMOL,MONTPELLIER,FRANCE

来源：

TETRAHEDRON LETTERS | 1996年 / 37卷 / 32期

关键词：

D O I：

10.1016/0040-4039(96)01195-1

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The synthesis of chloroethylnitrososulfamides (CENS), was carried out starting from chlorosulfonyl isocyanate, amines and haloalcohols through heterocyclization and decarboxylative reopening of N-sulfamoyl-2-oxazolidinones. A total regioselectivity concerning CO2 versus SO2 site hydrolysis was observed. A related aminolysis of sulfamoyloxazolidinones gave N-carbamoylsulfamides. The specific nitrosation on the N-chloroalkyl moiety can be obtained after methylation of the sulfamoyloxazolidinones. Copyright (C) 1996 Elsevier Science Ltd

引用

页码：5695 / 5698

页数：4

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