Grey matter and social functioning correlates of glutamatergic metabolite loss in schizophrenia

被引：94

作者：

Aoyama, Naoko ^{[1
,4
]}

Theberge, Jean ^{[1
,2
,3
,4
,7
]}

Drost, Dick J. ^{[1
,2
,3
,4
,7
,8
]}

Manchanda, Rahul ^{[2
]}

Northcott, Sandra ^{[2
]}

Neufeld, Richard W. J. ^{[2
,5
]}

Menon, Ravi S. ^{[3
,4
,8
]}

Rajakumar, Nagalingam ^{[2
,6
]}

Pavlosky, William F. ^{[3
,7
]}

Densmore, Maria ^{[1
,2
]}

Schaefer, Betsy ^{[2
]}

Williamson, Peter C. ^{[1
,2
,3
,4
,7
,8
]}

机构：

[1] Lawson Hlth Res Inst, London, ON, Canada

[2] Univ Western Ontario, Dept Psychiat, London, ON N6A 3K7, Canada

[3] Univ Western Ontario, Dept Med Imaging, London, ON N6A 3K7, Canada

[4] Univ Western Ontario, Dept Med Biophys, London, ON N6A 3K7, Canada

[5] Univ Western Ontario, Dept Psychol, London, ON N6A 3K7, Canada

[6] Univ Western Ontario, Dept Anat & Cell Biol, London, ON N6A 3K7, Canada

[7] St Josephs Hlth Care, Dept Diagnost Imaging, London, ON, Canada

[8] Roberts Res Inst, Ctr Funct & Metab Mapping, London, ON, Canada

来源：

BRITISH JOURNAL OF PSYCHIATRY | 2011年 / 198卷 / 06期

基金：

加拿大健康研究院;

关键词：

MAGNETIC-RESONANCE-SPECTROSCOPY; VOXEL-BASED MORPHOMETRY; ANTERIOR CINGULATE; PROTON MRS; GLUTAMINE; EPISODE; PATHOPHYSIOLOGY; THALAMUS;

D O I：

10.1192/bjp.bp.110.079608

中图分类号：

R749 [精神病学];

学科分类号：

100204 [神经病学];

摘要：

Background Thalamic glutamine loss and grey matter reduction suggest neurodegeneration in first-episode schizophrenia, but the duration is unknown. Aims To observe glutamine and glutamate levels, grey matter volumes and social functioning in patients with schizophrenia followed to 80 months after diagnosis. Method Grey matter volumes and proton magnetic resonance spectroscopy metabolites in left anterior cingulate and left thalamus were measured in 17 patients with schizophrenia before medication and 10 and 80 months after diagnosis. Social functioning was assessed with the Life Skills Profile Rating Scale (LSPRS) at 80 months. Results The sum of thalamic glutamate and glutamine levels decreased over 80 months, and correlated inversely with the LSPRS. Thalamic glutamine and grey matter loss were significantly correlated in frontal, parietal, temporal and limbic regions. Conclusions Brain metabolite loss is correlated with deteriorated social functioning and grey matter losses in schizophrenia, consistent with neurodegeneration.

引用

页码：448 / 456

页数：9

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