The cytokine-serum amyloid A-chemokine network

被引：107

作者：

De Buck, Mieke ^{[1
]}

Gouwy, Mieke ^{[1
]}

Wang, Ji Ming ^{[2
]}

Van Snick, Jacques ^{[3
,4
]}

Proost, Paul ^{[1
]}

Struyf, Sofie ^{[1
]}

Van Damme, Jo ^{[1
]}

机构：

[1] Univ Leuven, KU Leuven, Dept Microbiol & Immunol, Rega Inst Med Res,Lab Mol Immunol, Minderbroedersstr 10, B-3000 Leuven, Belgium

[2] NCI, Canc & Inflammat Program, Ctr Canc Res, Frederick, MD 21702 USA

[3] Brussels Branch, Ludwig Canc Res, Brussels, Belgium

[4] Catholic Univ Louvain, de Duve Inst, Brussels, Belgium

来源：

CYTOKINE & GROWTH FACTOR REVIEWS | 2016年 / 30卷

关键词：

SAA; FPR2; Chemotaxis; Cytokines; TLR2; NECROSIS-FACTOR-ALPHA; C-REACTIVE PROTEIN; NF-KAPPA-B; ACUTE-PHASE RESPONSE; MACROPHAGE INFLAMMATORY PROTEIN-1-ALPHA; ENDOTHELIAL-CELL INTERACTIONS; SIGNAL-TRANSDUCTION PATHWAY; INTESTINAL EPITHELIAL-CELLS; MESSENGER-RNA EXPRESSION; HIGH-DENSITY-LIPOPROTEIN;

D O I：

10.1016/j.cytogfr.2015.12.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Levels of serum amyloid A (SAA), a major acute phase protein in humans, are increased up to 1000-fold upon infection, trauma, cancer or other inflammatory events. However, the exact role of SAA in host defense is yet not fully understood. Several pro- and anti-inflammatory properties have been ascribed to SAA. Here, the regulated production of SAA by cytokines and glucocorticoids is discussed first. Secondly, the cytokine and chemokine inducing capacity of SAA and its receptor usage are reviewed. Thirdly, the direct (via FPR2) and indirect (via TLR2) chemotactic effects of SAA and its synergy with chemokines are unraveled. Altogether, a complex cytokine-SAA-chemokine network is established, in which SAA plays a key role in regulating "the inflammatory response. (C) 2015 Elsevier Ltd. All rights reserved.

引用

页码：55 / 69

页数：15

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