(1H-Imidazo[4,5-c]pyridin-2-yl)-1,2,5-oxadiazol-3-ylamine derivatives:: A novel class of potent MSK-1-inhibitors

被引：40

作者：

Bamford, MJ

Alberti, MJ

Bailey, N

Davies, S

Dean, DK

Gaiba, A

Garland, S

Harling, JD

Jung, DK

Panchal, TA

Parr, CA

Steadman, JG

Takle, AK

Townsend, JT

Wilson, DM

Witherington, J

机构：

[1] GlaxoSmithKline Pharmaceut, Neurol & GI Ctr Excellence Drug Discovery, Harlow CM19 5AW, Essex, England

[2] High Throughput Chem, Res Triangle Pk, NC 27709 USA

[3] GlaxoSmithKline Pharmaceut, Computat & Struct Sci, Harlow CM19 5AW, Essex, England

[4] Cardiovasc & Urol CEDD, Med Res Ctr, Stevenage SG1 2NY, Herts, England

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2005年 / 15卷 / 14期

关键词：

MSK-1; mitogen and stress-activated protein kinase; imidazo[4,5-c]pyridine;

D O I：

10.1016/j.bmcl.2005.05.021

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A novel series of imidazo[4,5-c]pyridines bearing a 1,2,5-oxadiazol-3-ylamine functionality has been developed. These are potent inhibitors of mitogen and stress-activated protein kinase-1. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：3402 / 3406

页数：5

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