Two-stage enzyme mediated drug release from LMWG hydrogels

被引:120
作者
van Bommel, KJC
Stuart, MCA
Feringa, BL
van Esch, J
机构
[1] Biomade Technol Fdn, NL-9747 AG Groningen, Netherlands
[2] Univ Groningen, Stratingh Inst, Dept Organ & Mol Inorgan Chem, NL-9747 AG Groningen, Netherlands
关键词
D O I
10.1039/b507157g
中图分类号
O62 [有机化学];
学科分类号
070303 ; 081704 ;
摘要
An enzymatically cleavable low molecular weight gelator-(model) drug conjugate system can be employed to effect a two-step enzyme mediated drug release, demonstrating the potential of LMWG systems for the development of drug delivery devices.
引用
收藏
页码:2917 / 2920
页数:4
相关论文
共 25 条
[1]   Hierarchical self-assembly of chiral rod-like molecules as a model for peptide β-sheet tapes, ribbons, fibrils, and fibers [J].
Aggeli, A ;
Nyrkova, IA ;
Bell, M ;
Harding, R ;
Carrick, L ;
McLeish, TCB ;
Semenov, AN ;
Boden, N .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2001, 98 (21) :11857-11862
[2]   6-AMINOQUINOLINE AS A FLUOROGENIC LEAVING GROUP IN PEPTIDE CLEAVAGE REACTIONS - A NEW FLUOROGENIC SUBSTRATE FOR CHYMOTRYPSIN [J].
BRYNES, PJ ;
BEVILACQUA, P ;
GREEN, A .
ANALYTICAL BIOCHEMISTRY, 1981, 116 (02) :408-413
[3]  
Chourasia MK, 2003, J PHARM PHARM SCI, V6, P33
[4]   Matrix metalloproteinases: molecular aspects of their roles in tumour invasion and metastasis [J].
Curran, S ;
Murray, GI .
EUROPEAN JOURNAL OF CANCER, 2000, 36 (13) :1621-1630
[5]   11-Aminoundecanoic acid:: a versatile unit for the generation of low molecular weight gelators for water and organic solvents [J].
D'Aléo, A ;
Pozzo, JL ;
Fages, F ;
Schmutz, M ;
Mieden-Gundert, G ;
Vögtle, F ;
Caplar, V ;
Zinic, M .
CHEMICAL COMMUNICATIONS, 2004, (02) :190-191
[6]   Water gelation by small organic molecules [J].
Estroff, LA ;
Hamilton, AD .
CHEMICAL REVIEWS, 2004, 104 (03) :1201-1217
[7]   Entrapment and release of quinoline derivatives using a hydrogel of a low molecular weight gelator [J].
Friggeri, A ;
Feringa, BL ;
van Esch, J .
JOURNAL OF CONTROLLED RELEASE, 2004, 97 (02) :241-248
[8]  
FRIGGERI A, 2005, IN PRESS CHEM EUR J
[9]  
Gronwald O, 2001, CHEM-EUR J, V7, P4328, DOI 10.1002/1521-3765(20011015)7:20<4328::AID-CHEM4328>3.0.CO
[10]  
2-S