Enantioselective synthesis of (-)-indolizidine 167B

被引：55

作者：

Chalard, P

Remuson, R ^{[1
]}

Gelas-Mialhe, Y

Gramain, JC

Canet, I

机构：

[1] CNRS, F-63177 Clermont Ferrand, France

[2] Univ Blaise Pascal, F-63177 Clermont Ferrand, France

来源：

TETRAHEDRON LETTERS | 1999年 / 40卷 / 09期

关键词：

allylsilane; acyliminium ion; alkaloid; indolizidine;

D O I：

10.1016/S0040-4039(99)00059-3

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The enantioselective total synthesis of (-)-indolizidine 167B is described. The key step is the intramolecular cyclization of the chiral N-acyliminium ion 6. Indolizidine 167B was obtained in 7 steps and 17% yield from ethyl (R)-3-aminohexanoate, with an enantiomeric excess of 93%. (C) 1999 Elsevier Science Ltd. All rights reserved.

引用

页码：1661 / 1664

页数：4

共 25 条

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