Cardiolipin oxidation sets cytochrome c free

被引：105

作者：

Orrenius, S ^{[1
]}

Zhivotovsky, B ^{[1
]}

机构：

[1] Karolinska Inst, Div Toxicol, Inst Environm Med, SE-17177 Stockholm, Sweden

来源：

NATURE CHEMICAL BIOLOGY | 2005年 / 1卷 / 04期

关键词：

D O I：

10.1038/nchembio0905-188

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Cytochrome c release from the mitochondria is a critical component of the apoptotic cell-death program. Cytochrome c-catalyzed peroxidation of cardiolipin, a mitochondrial phospholipid, has now been shown to lessen the binding of cytochrome c to the mitochondrial inner membrane and facilitate permeabilization of the outer membrane. These results describe a new and earlier pro-apoptotic role for cytochrome c.

引用

页码：188 / 189

页数：2

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