A study of maternally derived measles antibody in infants born to naturally infected and vaccinated women

被引:55
作者
Brugha, R
Ramsay, M
Forsey, T
Brown, D
机构
[1] PUBL HLTH LAB SERV,CTR COMMUNICABLE DIS SURVEILLANCE,IMMUNISAT DIV,LONDON NW9 5EQ,ENGLAND
[2] NATL INST BIOL STAND & CONTROLS,POTTERS BAR EN6 3QG,HERTS,ENGLAND
[3] CENT PUBL HLTH LAB,PHLS,DIV VIRUS REFERENCE,LONDON NW9 5HT,ENGLAND
关键词
D O I
10.1017/S0950268800059203
中图分类号
R1 [预防医学、卫生学];
学科分类号
1004 ; 120402 ;
摘要
Maternal, cord and infant measles antibody levels were measured and compared in a group of 411 vaccinated mothers and 240 unvaccinated mothers, and their babies, between 1983 and 1991. Maternal and cord sera were tested by haemagglutination inhibition and/or enzyme-linked immunosorbent assay, and plaque reduction neutralization tests were also used to test infant sera. Geometric mean titres were significantly higher in the unvaccinated than in the vaccinated mothers (P < 0.001). Infants born to mothers with a history of measles had higher antibody levels at birth than infants of vaccinated mothers and, although the difference narrowed over time, continued to have higher levels up to 30 weeks of age. Between 5 and 7 months of age significantly more of the children of vaccinated mothers had plaque reduction neutralization antibody levels below that which would interfere with vaccination. As the boosting effect of circulating natural measles disappears, earlier measles vaccination may need to be considered, perhaps as part of a two-dose policy.
引用
收藏
页码:519 / 524
页数:6
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