Longitudinal changes in aging brain function

被引：43

作者：

Beason-Held, L. L. ^{[1
]}

Kraut, M. A. ^{[2
]}

Resnick, S. M. ^{[1
]}

机构：

[1] NIA, NIH, Lab Personal & Cognit, Baltimore, MD 21224 USA

[2] Johns Hopkins Univ, Sch Med, Dept Radiol, Baltimore, MD 21218 USA

来源：

NEUROBIOLOGY OF AGING | 2008年 / 29卷 / 04期

关键词：

positron emission tomography; functional imaging; neuroimaging; brain function; age; aging; verbal; spatial; memory;

D O I：

10.1016/j.neurobiolaging.2006.10.031

中图分类号：

R592 [老年病学]; C [社会科学总论];

学科分类号：

03 ; 0303 ; 100203 ;

摘要：

Changes in brain activity over time were evaluated in a group of older adults in the Baltimore Longitudinal Study of Aging who maintained good physical and cognitive health. Participants underwent PET scans during rest and delayed verbal and figural recognition memory performance at year I baseline and at year 9. While memory performance remained stable over the 8 years, longitudinal changes in regional cerebral blood flow were observed within each scan condition. Further analyses revealed distinctive patterns of change related specifically to verbal or figural recognition, as well as longitudinal changes common to all scan conditions. These findings demonstrate that the older brain undergoes functional reorganization with increasing age in healthy, cognitively stable individuals. In view of the stable memory performance, the task-dependent results suggest that age-related changes in brain activity help maintain cognitive function with advancing age. (C) 2006 Elsevier Inc. All rights reserved.

引用

页码：483 / 496

页数：14

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