Cyclic ADP-ribose as a second messenger revisited from a new aspect of signal transduction from receptors to ADP-ribosyl cyclase

被引：47

作者：

Higashida, H

Hashii, M

Yokoyama, S

Hoshi, N

Chen, XL

Egorova, A

Noda, M

Zhang, JS

机构：

[1] Kanazawa Univ, Grad Sch Med, Dept Biophys Genet Mol Med & Bioinformat, Kanazawa, Ishikawa 9208640, Japan

[2] Krasnoyarsk State Med Acad, Dept Pathophysiol, Krasnoyarsk 660022, Russia

[3] Kyushu Univ, Grad Sch Pharmaceut Sci, Lab Pathophysiol, Fukuoka 8128582, Japan

来源：

PHARMACOLOGY & THERAPEUTICS | 2001年 / 90卷 / 2-3期

关键词：

Ca2+ signaling; ryanodine receptors; Ca2+-induced Ca2+ release; ADP-ribosyl cyclase; cyclic ADP-ribose hydrolase; CD38; neurotransmitter receptors;

D O I：

10.1016/S0163-7258(01)00142-5

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Cyclic ADP-ribose (cADPR), an endogenous modulator of ryanodine receptor Ca2+ -releasing channels, is found in various tissues. Cytosolic injection of cADPR induces an elevation of intracellular Ca2+ concentrations or potentiates Ca2+ increases. cADPR facilitates neurotransmitter or insulin release and modifies ionic currents. cADPR is synthesized by ADP-ribosyl cyclase and is metabolized by cADPR hydrolase. ADP-ribosyl cyclase activity is up-regulated by nitric oxide/cyclic GMP-dependent phosphorylation or receptor stimulation via G-proteins within membranes. These findings suggest that cADPR is a second messenger in cellular Ca2+ signaling. However, many intriguing issues remain to be addressed before this identity is confirmed. (C) 2001 Elsevier Science Inc. All rights reserved.

引用

页码：283 / 296

页数：14

共 138 条

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